OBJECTIVE Systemic sclerosis (SSc) is an autoimmune disease clinically manifesting as progressive fibrosis of the skin and internal organs. Cadherin-11 (CDH11) expression is increased in fibrotic skin and lung tissue. Targeting CDH11 may be an effective approach to treating fibrosis. We hypothesize that targeting CDH11 will decrease fibrosis in the tight skin-1 (Tsk-1) mouse model. METHODS CD...

Three classes of signaling molecule, VG1, WNT and BMP, play crucial roles in axis formation in the chick embryo. Although VG1 and WNT signals have a pivotal function in inducing the primitive streak and Hensen's node in the embryo midline, their action is complemented by that of BMP antagonists that protect the prospective axial tissue from the inhibitory influence of BMPs secreted from the per...

In this work, the conformational space of the pseudosaccharyl ether 3-(allyloxy)-1,2-benzisothiazole 1,1-dioxide (ABID) has been studied by means of infrared spectroscopy and density functional theory (DFT) calculations. Five different low energy conformers (TSk, TC, GSk, GSk' and GC, with relative energies of 0.00, 1.97, 2.00, 3.82 and 6.02 kJ mol(-1), respectively) were found on the DFT(B3LYP...

This paper introduces a higher-order Takagi-SugenoKang (TSK) neuro-fuzzy inference system and its applications in medical decision support systems. Different from most TSK fuzzy systems that utilize first-order TSK type fuzzy rules, the proposed system is composed of higherorder TKS fuzzy rules that have functions in their consequent parts of the following type: y = b0 x1 b1 x2 ...xp . The type...

OBJECTIVE To assess the factor structure of the Chinese version of the Tampa Scale for Kinesiophobia (TSK). DESIGN Chinese patients with chronic pain attending either orthopaedic specialist services (n = 216) or multidisciplinary specialist pain services (n = 109) participated in this study. METHODS Subjects completed the Chinese version of TSK, The Chronic Pain Grade Questionnaire, Hospita...

The Wnt signaling pathway is essential for the development of diverse tissues during embryogenesis. Signal transduction is activated by the binding of Wnt proteins to the type I receptor low-density lipoprotein receptor-related protein 5/6 and the seven-pass transmembrane protein Frizzled (Fzd), which contains a Wnt-binding site in the form of a cysteine-rich domain. Known extracellular antagon...

Through sequence-based classification, this paper tries to accurately predict the DNA binding sites of transcription factors (TFs) in an unannotated cellular context. Related methods in the literature fail to perform such predictions accurately, since they do not consider sample distribution shift of sequence segments from an annotated (source) context to an unannotated (target) context. We, th...

The Mamdani and TSK fuzzy models are fuzzy inference engines which have been most widely applied in real-world problems. Compared to the Mamdani approach, the TSK approach is more convenient when the crisp outputs are required. Common to both approaches, when a given observation does not overlap with any rule antecedent in the rule base (which usually termed as a sparse rule base), no rule can ...

conclusions there were significant distinctions in the skin temperature distribution during exercise according to the activity of the area under consideration during exercise, which may be important in the development of physiological models and heat flux analyses for different purposes. results during pre-exercise, all tsk reached a steady-state (p ≤ 0.05), which ensured adequate thermal stabi...