To gain a complete understanding of a chemical reaction, it is necessary to determine the structural changes that occur to the reacting molecules during the reaction. Chemists have long dreamed of being able to determine the molecular structure changes that occur during a chemical reaction, including the structures of transition states (TSs). The use of ultrafast spectroscopy to gain a detailed...

Heterogeneous Chip MultiProcessors (CMP)s, which combine processor cores with specialized HW accelerators, are one main approach to high-performance low-power computing. While it is promising for few accelerators, the scalability is a major challenge with increasing number of accelerators. Resources including memory, communication fabric and processor turn into bottlenecks and result in acceler...

Postoperative changes in endocrinological status and serum chemistry during the 4 years after transsphenoidal surgery (TSS) in 25 dogs with Cushing's disease were investigated in a prospective study. In all 25 dogs, Cushing's disease was diagnosed from resected pituitary tissues as a corticotroph adenoma in the anterior lobe of the pituitary. Prior to TSS, all 25 dogs showed hypercortisolemia. ...

With the widespread use of Next Generation Sequencing technologies, the primary bottleneck of genetic research has shifted from data production to data analysis. However, heterogeneous data sets makes comparisons and integration challenging and time consuming. Here, we apply a data interoperability approach that provides unambiguous (machine readable) description of genomic annotations based on...

We herein report a case of toxic shock syndrome (TSS) associated with the 2009 pandemic H1N1 (pH1N1) influenza virus and a community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in a 16-year-old Vietnamese girl. Staphylococcal enterotoxin B (SEB) was detected in the patient's serum, and the level of anti-SEB antibodies was found to be elevated. A flow cytometric anal...

BACKGROUND Seven years after implementing a new curriculum an evaluation was performed to explore possibilities for improvements. PURPOSES To analyze students' study habits in relation to exam frequency and to evaluate effectiveness of instruction. METHODS Time spent on self study (TSS) and the quantity of instruction (QI) was assessed during the internal medicine and the surgical semester....

Life-threatening infections caused by Staphylococcus aureus, particularly the community-acquired methicillin-resistant strains of S. aureus, continue to pose serious problems. Greater virulence and increased pathogenicity of certain S. aureus strains are attributed to higher prevalence of exotoxins. Of these exotoxins, the superantigens (SAg) are likely most pathogenic because of their ability ...

OBJECTIVE Following transsphenoidal surgery (TSS), it is important to assess for and manage adrenal insufficiency (AI). The goal of this study is to assess the efficacy and safety of a glucocorticoid (GC) sparing protocol to limit GC exposure in patients undergoing TSS. METHODS Adult patients undergoing TSS (excluding Cushing disease) with adequate adrenal function prior to surgery underwent ...

It has long been a concern that performance measures of species distribution models react to attributes of the modeled entity arising from the input data structure rather than to model performance. Thus, the study of Allouche et al. (Journal of Applied Ecology, 43, 1223, 2006) identifying the true skill statistics (TSS) as being independent of prevalence had a great impact. However, empirical e...

An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 d...