Potent immunoadjuvants are needed to elicit responses following mucosal delivery. PLGA (poly[D,L-lactic-co-glycolic acid]) nanospheres, Quillaja saponin (QS) and cross-linked dextran microspheres (CDM) as drug delivery and absorption enhancer adjuvants were evaluated. PLGA nanospheres were prepared by solvent evaporation method. Particulate characteristics of nanospheres were studied by optical...

BACKGROUND It is unknown if discontinuation of targeted therapy (TT) and readministration in case of recurrence is feasible in patients with metastatic renal cell carcinoma (mRCC) in which complete response (CR) is achieved by TT alone or no evidence of disease (NED) with additional resection of residual metastases. PATIENTS AND METHODS Patients in whom TT was discontinued after CR to TT alon...

ABSTRACT The two most successful methods for exoplanet detection rely on the of planetary signals in photometric and radial velocity time-series. This depends numerical techniques that exploit synergy between data theory to estimate planetary, orbital, and/or stellar parameters. In this work, we present a new version modelling code pyaneti. release has special emphasis built-in multidimensional...