T-type calcium channels (T/Ca(v)3-channels) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer. T-channels are the target of endogenous signaling lipids including the endocannabinoid anandamide, the ω3-fatty acids, and the lipoamino-acids. However, the precise molecular mechanism by which these molecules inhibit T-cur...

BACKGROUND Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially mimicked the appetite-stimulating and weight-inducing effects found in the clinical setting. Antipsychotic-induced effects on serum lipids are also inconsistent in rats, but in...

The Time-Triggered Architecture (TTA) provides a computing infrastructure for the design and implementation of dependable distributed embedded systems. A large real-time application is decomposed into nearly autonomous clusters and nodes and a fault-tolerant global time base of known precision is generated at every node. In the TTA this global time is used to precisely specify the interfaces am...

Low-power design became crucial with the widespread use of the embedded systems, where a small battery has to last for a long period. The embedded processors need to efficient in order to achieve real-time requirements with low power consumption for specific algorithms. Transport Triggered Architecture (TTA) offers a cost-effective trade-off between the size and performance of ASICs and the pro...

ANG II promotes inflammation through nuclear factor kappa beta (NF-kB) mediated induction of cytokines and radical oxidants species (ROS). The aim of the present study was to examine the effect of TTA, a modified fatty acid, on NF-kB, pro-inflammatory markers, ROS and nitric oxide (NO) production in 2K1C hypertension. 2K1C TTA treated group had lower blood pressure (128 ± 3 mmHg) compared to 2K...

OBJECTIVE Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator-activated receptors (PPARs). Human endothelial cells express PPARs. We hypothesized that TTA could modulate endothelial cell activation at least partly through PPAR-related mechanisms. METHODS AND RESULTS We explored this hypothesis by diffe...

MOTIVATION TTA Lynx is a web-based service for finding, assessing and comparing coding sequences that contain TTA codons. This codon is most notable for being a regulatory switch that governs different aspects of the physiology of several GC-rich, Gram-positive bacteria belonging to genus Streptomyces, prolific producers of clinically important natural products. The ever-increasing pace of geno...

This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examine...

The prime requirements for the spin transfer torque based ferromagnetic (FM)/nonmagnetic (NM) bilayer spin devices are (i) the absence of two-magnon scattering (TMS) noise, (ii) minimum energy dissipation and (iii) fast switching. To realize these objectives we have studied the thickness, Py (permalloy) thicknesses (tPy) and b-Ta thicknesses (tTa), dependent magnetization dynamics behaviour of ...

We hereby present a simple method for reducing the effect of oxygen quenching in Triplet-Triplet Annihilation Upconversion (TTA-UC) systems. A number of commercially available thioethers and one thiol have been tested as singlet oxygen scavengers. Recording of the upconverted emission from a well-studied PdOEP (sensitizer)-DPA (annihilator/emitter) couple has been made over time with steady-sta...