Background: Tuberculosis (TB) is a major cause of death worldwide. Finding an effective vaccine against TB is the best way to control it. Several vaccines against this disease have been developed but none are completely protective. The aim of this study was to design and construct a cloning vector containing the Mycobacterium tuberculosis (M. tuberculosis) heat shock protein X (hspX). Metho...

Tuberculosis is a highly infectious disease. It usually infects the lung, but dissemination to different organs results in severe form of tuberculosis, i.e., disseminated tuberculosis. The situation becomes even more challenging when infection due multidrug-resistant strains Mycobacterium present case very rare one where 17-year-old Indian girl presented with headache, vomiting, cough expectora...

extrapulmonary tuberculosis is a complication of pulmonary tuberculosis that is disseminated through hematogenous or lymphatic system and may involve any organs. we present a case of primary tuberculosis of the penis that is a very rare presentation of tuberculosis. patient the patient was a 43-year-old man who had kidney transplantation. he admitted with painful ulceration on the glans of peni...

Tuberculosis (TB) is the oldest documented infectious disease. Fragments of the spinal column from Egyptian mummies from 2400 B.C. shows definite pathological signs of tubercular decay. The term phthisis (consumption) appears first in Greek literature. Hypocrates identified phthisis as the most widespread disease of the times around 460 B.C. Exact pathological and anatomical descriptions of the...

Background: Mycobacterium tuberculosis lipid antigens take part in pathogenicity of the bacterium but the response of monocytes/macrophages to these antigens in tubercu-losis is not well known. Objective: The aim of current investigation was to study the M. tuberculosis lipid antigens in tuberculosis pathogenesis. Methods: In the present study M. tuberculosis lipid antigens were extracted. Mono...

We investigated the use of DNA amplification by polymerase chain reaction (peR) for detection of Mycobacterium tuberculosis in 300 patients who were suspected of having pulmonary tuberculosis and compared the results with culture results which were performed in parallel with PCR. Two-thirds of each sample was processed for smear and culture by standard methods and one-third was prepared fo...

multifocal skeletal tuberculosis in not uncommon in the countries with tuberculosis. the clinical onest is insidious and sometimes nonspecific, resulting in delay or misdiagnosis. bone scan appearance is presented in some reports, as multiple abnormal accumulations of tracer. this report describes an unusual presentation of multifocal skeletal tuberculosis.

background mycobacterium tuberculosis is a vicious microbe co-existing with the infected host. this pathogen exploited opportunities to spread during periods of urbanization and social upheaval, and got retreated with improved hygiene. objectives this investigation was designed to clone and characterize m. tuberculosis mutt gene, a homologue of a dna repair protein in escherichia coli. the aim ...

Introduction: Tuberculosis is a communicable disease caused by mycobacterium tuberculosis that primarily affects the lungs. Primary tuberculosis of the nose in the pediatric age group is rare. The diagnosis of this common entity in the present case was challenging.   Case Report: We report the case of a 3-year old girl who presented with a painless swelling over the dorsum of the nose for 7 mon...