objective(s): several beneficial effects have been attributed to the probiotic lactic acid bacteria. it was determined that lactobacilli can exert antiproliferative effects on the various cancer cell lines including colon cancer. effects of lactic acid bacteria on colon cancer may vary from strain to strain and there is a need to find the new probiotic strains with tumor suppressing properties ...

Breast cancer cell lines have been widely used for breast cancer modelling which encompasses a panel of diseases with distinct phenotypical associations. Though cell lines provide unlimited homogenous materials for tumor studies and are relatively easy to culture, they are known to accumulate mutations duringthe initial establishment and subsequent series of cultivations. Thus, whether breast c...

Metastasis describes the ability of a tumor to invade normal tissue and generate secondary tumors at sites distant from the primary tumor. The mechanism responsible for the inhibition of tumor metastasis by different agents is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness. Certainly effective treatment of metasta...

Tumor cells regulate their progression not only by the factors within cell bodies but also secretome they produce and secrete. While significantly alters fate of tumor themselves, growth surrounding including both companion cancer non-cancer cells. consists varying molecules that have been reported mostly tumor-promotive. Furthermore, pro-tumor capability is enhanced application chemotherapeuti...

obtaining a continuous source of normal cells or dna from a single individual has always been a rate limiting step in biomedical research. availability of lymphoblastoid cell lines (lcls) as a surrogate for isolated or cryopreserved peripheral blood lymphocytes has substantially accelerated the process of biological investigations. lcls can be established by in vitro infection of resting b cell...

the optimization of cell culture conditions for growth and productivity of recombinant chinese hamster ovary (cho) cells is a critical step in biopharmaceutical manufacturing. in the present study, the effects of the timing and amount of peptone feeding of a recombinant cho cell line grown in a basal medium in serum-free suspension culture were determined for eight peptones of different origin ...

As number of cancer patients increasing, the chemotherapy treatments are also increasing. This analysis aims to provide a cutting-edge outline antineoplastic medications extracted from streptomyces. Streptomyces main source antibiotic production. Antineoplastic moderate pace tumor development and postpone metastasis. The utilization performance methods discussed, with focus on drugs. produces c...

sertoli cell tumors of the testis are extremely rare tumors with a heterogeneous pathology. three histological variants have been described: sertoli cell tumor not otherwise specified (nos), large cell calcifying sertoli cell tumor and the sclerosing sertoli cell tumor. the sclerosing sertoli cell tumor described herein is associated with prominent stromal sclerosis. they present as painless sc...

Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor cells. The basis for sensitivity and resistance to the antitumor effects of this agent remains unclear. The present studies have monitored the effects of TNF on 14 epithelial tumor cell lines. Eleven of these cell lines were resistant to the growth inhibitory effects of TNF (50% inhibitory concentrat...