Tumour immunotherapy is aimed at the stimulation of the otherwise inactive immune system to remove, or at least to restrict, the growth of the original tumour and its metastases. The tumour-immune system interactions involve the stimulation of the immune response by tumour antigens, but also the tumour induced death of lymphocytes. A system of two non-linear ordinary differential equations was ...

Patients with resectable oesophageal cancer (OeC) have a 25-47% 5-year overall survival (OS). The strongest prognostic factor is pathological lymph node (LN) status. Regional tumour-draining LNs play an important role in the host anti-tumour immune response. We previously demonstrated that microarchitecture tumour-negative (LNneg) changes after chemotherapy and predicts OS. It currently unknown...

Granulomatous response in association with breast cancer and within the cancer draining lymph nodes is an extremely rare phenomenon. Granulomatous inflammation is an immune response commonly seen against infectious agents and certain non-neoplastic conditions. The etiopathogenesis of granulomas associated with malignancies is not clear but it may be because of an immunologic reaction to tumour ...

Rhabdomyosarcoma encompasses a group of malignant myogenic neoplasms expressing a multitude of clinical and pathological diversities. It is the commonest soft tissue sarcoma of childhood but neonates are rarely affected. Embryonal subtype is the most frequent. Head-neck and genitourinary tracts are predominant sites, while trunk is considered among the unusual sites of rhabdomyosarcoma. Herein ...

In 1991, Handlers and colleagues described the Central odontogenic fibroma (COF) as a distinct entity which is a rare benign odontogenic tumour and up to the present, only 78 cases of it have been published. COF usually occurs in an adult patient and has a predilection for the anterior region of the jaws. A 2.8:1 female to mail ratio is typically noted. This article presents a case of COF in a ...