OBJECTIVE To describe the performance of alcohol screening questionnaires in female patients. DATA SOURCES We searched MEDLINE from 1966 to July 1997 for alcoholism or alcohol-drinking and for CAGE, AUDIT, BMAST, TWEAK, T-ACE, MAST, SMAST, or SAAST; Citations Indexes for newer screening questionnaires and those without acronyms; and MEDLINE from 1996 to July 1997 for alcoholism or alcohol-dri...

AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil (5-FU)-induced diarrhea. METHODS Diarrhea was induced in wild-type (WT), Fn14 knockout (KO), and IL-13 receptor (IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinoma-bearing mice were co-tr...

MicroRNAs (miRNAs) are important regulators of gene expression and have been implicated in immunity inflammation. Chronic skin inflammation psoriasis is maintained by inflammatory circuits involving infiltrating immune cells keratinocytes. Recently we identified microRNA(miR)-149 to be suppressed keratinocytes showed that it acts as a link between IFN-g the TWEAK pathways. To further explore ro...

The mechanisms underlying hepatic inflammation and fibrogenesis in chronic hepatitis B (CHB) are complex and several cytokines are involved. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily which also acts as a cytokine. This study was conducted to evaluate serum soluble TWEAK (sTWEAK) levels in noncirrhotic CHB patients.Fifty-two...

Abstract Background and Aims Butyrate is a well-known short-chain fatty acid (SCFAs) produced by the microbial fermentation of indigestible fibers. It contributes to colon homeostasis controls inflammatory responses in other tissues. thought play an important role pathogenesis kidney disease connections between diet, gut microbiota, disease. However, detailed characterization its function injur...