Tumor necrosis factor-like weak inducer of apoptosis (TWEAK/Tnfsf12) is a cytokine implicated in different steps associated with vascular remodeling. However, the role of TWEAK under hyperglycemic conditions is currently unknown. Using two different approaches, genetic deletion of Tnfsf12 and treatment with a TWEAK blocking mAb, we have analyzed the effect of TWEAK inhibition on atherosclerotic...

Malignant glioblastomas are characterized by their ability to infiltrate into normal brain.We previously reported that binding of the multifunctional cytokine TNF-like weak inducer of apoptosis (TWEAK) to its receptor fibroblast growth factor–inducible 14 (Fn14) induces glioblastoma cell invasion via Rac1 activation. Here, we show that Cdc42 plays an essential role in Fn14-mediated activation o...

TNF-like weak inducer of apoptosis (TWEAK) is a TNF family member with pleiotropic effects on a variety of cell types, one of which is the induction of proinflammatory cytokines by synovial fibroblasts derived from rheumatoid arthritis (RA) patients. In this study, we report that the serum TWEAK level was dramatically elevated during mouse collagen-induced arthritis (CIA) and blocking TWEAK by ...

BACKGROUND TWEAK (Tumor necrosis factor like WEAK inducer of apoptosis) is highly expressed by different immune cells and triggers multiple cellular responses, including control of angiogenesis. Our objective was to investigate its role in the human endometrium during the implantation window, using an ex-vivo endometrial microhistoculture model. Indeed, previous results suggested that basic TWE...

INTRODUCTION The aim of this study was to investigate the expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) in patients with polymyositis (PM) and dermatomyositis (DM), and their relation to clinical manifestations. METHODS Serum levels of TWEAK were detected in 98 PM/DM patients and 37 healthy controls by ...

BACKGROUND & AIMS Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis (TWEAK), is induced rapidly after PH and remains elevated throughout the period of peak hepatocyte replication. The role of Fn14 in post-PH liver regeneration is uncertain...

This study aims to explore the clinical value of urine TWEAK/Fn14 mRNA in lupus nephritis (LN) patients. Thirty one SLE (Systemic Lupus Erythematosus) patients with or without active LN and another 10 healthy controls were recruited. LN activity was assessed by SLE Disease Activity Index. Urinary expression of TWEAK, Fn14 and MCP-1 at the mRNA level was measured by RT-PCR. Urinary expression of...

The TWEAK system (Chapman 87) is a very nice synthesis of a long trend in planning and Artificial Intelligence, including STRIPS (Fikes & Nilsson 71). We derive a correctness criterion which is simpler that the one used for TWEAK since it does not involve modal operators and does not introduce neither white knights nor separation. This criterion is compared to the one of TWEAK and other related...

Objective To investigate the relationship between Tumor necrosis factor (TNF)-like weak inducer of apoptosis(TWEAK) and endometriosis. Methods TWEAK mRNA and protein concentrations in paired samples of eutopic endometrial tissue from women with and without endometriosis, and also of ectopic endometrial tissue from women with endometriosis were measured by Real-time PCR, immunohistochemistry and...

PURPOSE To explore the role of TWEAK in tumor growth and antitumor immune response and the activity and mechanism of RG7212, an antagonistic anti-TWEAK antibody, in tumor models. EXPERIMENTAL DESIGN TWEAK-induced signaling and gene expression were explored in tumor cell lines and inhibition of these effects and antitumor efficacy with RG7212 treatment was assessed in human tumor xenograft-, p...