BACKGROUND Recent decades have seen a constant upward projection in the prevalence of diabetes. Attempts to estimate diabetes prevalence rates based on relatively small population samples quite often result in underestimation. The aim of the present study was to investigate whether the Dutch diabetes prevalence estimate of 930 000 for 2013, based on a relatively small sample, still holds true w...

Diabetes includes various heterogeneous factors. Similar to subtypes of type 1 diabetes, 2 diabetes may show four subtype clusters. They are cluster A: severe insulin-deficient B: insulin-resistant C: mild obesity-related and D: age-related diabetes. Comparing them, the prevalence nephropathy cardiovascular events was highest in A. Reference data i) ratio A-D is 18.7%, 23.7%, 21.1%, 36.4%, ii) ...

There is no doubt that behavioral intervention is crucial for type 2 diabetes mellitus (T2DM) prevention and management. We aimed to estimate dietary habits and diet-oriented knowledge as well as the level of physical activity in 2500 insulin-treated Polish type 2 diabetes mellitus (T2DM) patients (55.4% women). The mean age of the study participants was 64.9 ± 9.3 years, mean BMI was 31.4 kg/m...

Introduction: Type 2 diabetes mellitus (T2DM) increases the risk of bone fractures. Objectives: This study aimed to examine use trabecular score (TBS) and BMD select best diagnostic tool for osteoporosis caused by type diabetes. Patients Methods: One hundred four patients (52 individuals with 52 ones without diabetes) aged at most 50 years were enrolled in a cross-sectional that was conducted d...

Background: Sex hormone-binding globulin (SHBG) regulates the levels of free sex hormones by sequestering circulating sex hormones and participates in some of the biological actions of sex hormones by mediating cellular uptake. Low circulating levels of sex hormone–binding globulin are a strong predictor of the risk of type 2 diabetes in women and men. However, it has been difficult to determin...

Microvascular pathophysiology associated with type 2 diabetes mellitus (T2DM) contributes to several aspects of the morbidity associated with the disease. We quantified the contribution of nitric oxide (NO) to the cutaneous vasodilator response to nonpainful local warming in subjects with T2DM (average duration of diabetes mellitus 7 +/- 1 yr) and in age-matched control subjects. We measured sk...

This article demonstrates changes in biochemical homeostasis patients with moderate SARS-CoV-2 and type 2 diabetes mellitus (T2DM) or hyperglycemia identified for the first time. The results of study were estimated according to indicators a blood test acute phase convalescent SARS-CoV-2. most significant deviations observed T2DM. development worsening due specific effect virus on carbohydrate m...

The ?-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) has been identified as the central initiator of ? (A?) generation in brain, key hallmark Alzheimer's disease (AD). However, recent studies provided evidence that BACE1 also plays a crucial role metabolic regulation, and we have shown neuronal human knock-in mice (PLB4) display type 2 diabetes mellitus (T2DM)-like symptoms alon...

Type 2 Diabetes mellitus (T2DM) is a chronic disorder of impaired insulin secretion and insulin resistance leading to hyperglycemia. In addition to hyperglycemia, dyslipidemia is a characteristic feature of T2DM. Progressive deterioration of beta-cell mass and function are the core pathogenic mechanisms underlying diabetes. Persistent hyperglycemia and hyperlipidemia are the major factors for l...