Dendritic cells (DCs) were shown to enhance UHMWPE particle promoted osteoclastogenesis in RAW264.7 macrophages. This study aimed to elucidate the signaling network mediating the osteoclastogenic effects of UHMWPE particles and DCs. RAW264.7 cells were induced with UHMWPE particles and /or DC2.4 cells. The expression of Rank was silenced by shRNA. The activation of p38MAPK, AKT, and NF-κB was i...

Macrophages constitute a major part of the cell response to wear particles produced at articulating and nonarticulating interfaces of joint replacements. This foreign body reaction can result in periprosthetic osteolysis and implant loosening. We demonstrate that ultra-high molecular weight polyethylene (UHMWPE) particles induce systemic trafficking of macrophages by noninvasive in vivo imaging...

Fluorinated graphene/ultra high molecular weight polyethylene (FG/UHMWPE) composites were prepared by ultrasonic dispersion and hot pressing. The mechanical propertys and tribological property of pure UHMWPE and FG/UHMWPE composites were investigated by micro hardness tester and high-speed reciprocating friction tester. The wear volume of the sample was measured by the scanning electron microsc...

Ultra high molecular weight polyethylene (UHMWPE) has been used as a load bearing and articulating counter face in total knee replacement (TKR) for over forty years1. However, wear debris generation of UHMWPE materials after their implantation in the human body has been proven to induce osteolysis and aseptic loosening, which is the main cause of long-term failure of TKR composed of UHMWPE and ...

Ultra-high molecular weight polyethylene (UHMWPE) has been the most commonly used bearing material in total joint arthroplasty. Wear and oxidation fatigue resistance of UHMWPE are regarded as two important properties to extend the longevity of knee prostheses. The present study investigated the accelerated ageing of UHMWPE in hydrogen peroxide highly oxidative chemical environment. The sliced s...

Ultra-high molecular weight polyethylene (UHMWPE) is extensively used in total joint replacements. Wear, fatigue, and fracture have limited the longevity of UHMWPE components. For this reason, significant effort has been directed towards understanding the failure and wear mechanisms of UHMWPE, both at a micro-scale and a macro-scale, within the context of joint replacements. We have previously ...

This work explores the effect of surface modification of stainless steel with a carbon nitride (CNx) film, under sliding wear of the UHMWPE/steel. Wettatibility of CNx coatings is assessed by means of the sessile drop method using two different liquid media. Microhardness and stiffness of CNx coatings are estimated by depth-sensing indentation. The sliding performance of UHMWPE against stainles...

Introduction: Ultra-high molecular weight polyethylene (UHMWPE) has been ubiquitous as a bearing surface material in joint arthroplasty for decades. Yet, its vulnerability to wear and fatigue failure following oxidation remains a major concern. Although significant gains in wear reduction and oxidation resistance have been achieved with a combination of cross-linking and heat treatments, these ...

Introduction: Ultra high molecular weight polyethylene (UHMWPE) components used in total joint replacements have rims and fillets that act as design stress risers; thus, it is of interest to determine the behavior UHMWPE under multiaxial loading conditions. Currently, there are a number of conventional and crosslinked UHMWPE formulations in clinical use in total hip and total knee replacement c...