It has been found previously that amilorides act via an allosteric site on the alpha(2A)-adrenergic receptor to strongly inhibit antagonist binding. In this study, allosteric modulation of agonist binding and function at the alpha(2A)-adrenergic receptor was explored. The dissociation rate of the agonist [(3)H]UK14304 from alpha(2A)-receptors was decreased by the amilorides in a concentration-d...

OBJECTIVES The objective of this study was to examine if, in the general population, physically active adults have less body fat after taking body mass index (BMI) into account. DESIGN A cross-sectional analysis of participants recruited into UK Biobank in 2006-2010. SETTING UK Biobank assessment centres throughout the UK. PARTICIPANTS 119 230 men and 140 578 women aged 40-69 years, with ...

UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and ...

A study on the prepayment behavior of Hong Kong mortgage loans is conducted. With all of the loans as adjustable-rate mortgages (ARMs), we nd that 1) Pre-payment speeds up and then slows down as the mortgage seasons; 2) Prepayment speeds up as the rate markup decreases; 3) Prepayment speeds up as the interest rate increases; 4) Prepayment speeds up when the prootability ratio of the banks (the ...

An ompD mutation caused by a Tn10 insertion was transduced into Salmonella typhimurium SL1344 and UK-1. The adherence and invasion capabilities of the resultant ompD mutants were examined by tissue culture analysis. The virulence of the S. typhimurium ompD mutants was ascertained by a 50% lethal dose (LD50) study and by determining colonization ability with BALB/c mice. We found no statisticall...

Image quality assessment is fundamental as it affects the level of confidence in any output obtained from image analysis. Clinical research imaging scans do not often come with an explicit evaluation of their quality, however reports are written associated to the patient/volunteer scans. This rich free-text documentation has the potential to provide automatic image quality assessment if efficie...

The technique introduced b y J eme for enumerat ing ant ibody-forming cells in agar (1, 2) permi ts precise analysis of the cellular kinetics of the immune response to sheep erythrocytes . I n an earlier paper the kinetic events and the a l terat ions in nucleic acid metabol ism observed during the induction of tolerance to this ant igen with the immunosuppressive drug cyclophosphamide were ana...

In this paper we present the idea of ergonomic instruments: musical devices that focus on minimising the learning curve of musicians by mapping inherent musical actions to the creation of music. We situate ergonomic instruments in the context of existing relevant work, and then discuss a new methodology towards the development of musical instruments including exploration of a musical goal which...