Background: The incidence of ulcerative colitis (UC) is rising in populations with western-style diet, rich in fat and protein, and low in fruits and vegetables. In the present study, we aimed to evaluate the association between dietary protein intakes and the risk of developing incident UC.   Methods : Sixty two cases of UC and 124 controls were studied using country-specific food frequency ...

Ulcerative colitis is characterized by crypt infiltration particularly of neutrophils. However, it is not known whether it reflects a primary crypt disorder or a secondary inflammatory response. In this study, we analyzed the expression profiles of histologically normal crypts microdissected from formalin-fixed biopsies of early stage ulcerative colitis. Total RNAs were extracted, amplified, an...

To determine if specific anticolon antibodies bound to colonic mucosa occur in ulcerative colitis, we obtained surgical specimens of colon from five patients with ulcerative colitis, one patient with diverticulitis, and three control subjects with carcinoma. Two specimens of ileum and cecum were also obtained from patients with Crohn ileocolitis. Tissue was homogenized and washed and bound Ig w...

Patients of ulcerative colitis are mostly managed by physicians. Surgeons play a very pivotal role in curative treatment and in dealing with complications of ulcerative colitis. Various technical advances made in the field have reduced surgical morbidity and mortality in these patients with improvement in the quality of life. The article discusses the role of surgery and various surgical option...

Left ventricular thrombi usually occur in the setting of an acute myocardial infarction, left ventricular aneurysm, or dilated cardiomyopathy. In the absence of ventricular wall motion abnormalities, they are rare. This report describes a patient with ulcerative colitis in whom two-dimensional echocardiography revealed a left intraventricular mass. Thrombosis in ulcerative colitis is a serious ...

The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such e...

BACKGROUND Ulcerative colitis is classically described as a condition originating in the rectum and extending proximally towards the cecum. In recent years, a discontinuous peri-appendiceal lesion has been described. Our aim was to evaluate the risk of progression to pancolitis in patients presenting with an isolated peri-appendiceal lesion on ileocolonoscopy. METHODS Endoscopy databases at t...

PURPOSE Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulated in colorectal cancer. This study was aimed to investigate the etiopathogenic role of AKR1B10 in ulcerative colitis and CAC. EXPERIMENTAL DESIGN...

In the study by Yoshino et al. [4] presented in this journal, 64 patients with ulcerative colitis refractory to immunosuppressive therapies (such as steroids and immunomodulators) were retrospectively enrolled and the clinical outcomes of GMA and immunosuppressive therapy after 2 weeks of ganciclovir treatment were investigated. The total colectomy rate in ulcerative colitis patients positive f...

the aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. the plasma concentrations of the four flavonoids were determined ...