OBJECTIVE The DIABHYCAR (type 2 DIABetes, Hypertension, CArdiovascular Events and Ramipril) study allowed investigators to analyze factors leading to the development of congestive heart failure (CHF) in type 2 diabetic patients with abnormal urinary albumin concentration. RESEARCH DESIGN AND METHODS Type 2 diabetic subjects of both sexes aged >or=50 years who had a urinary albumin concentrati...

BACKGROUND Urinary albumin levels and hypertension (HTN) are independently associated with an increased risk of all-cause mortality. The effect of albuminuria on mortality in the absence or presence of HTN is uncertain. This study aimed to evaluate the effect of albuminuria and HTN on all-cause and cardiovascular disease (CVD) mortality. METHODS Mortality outcomes for 32,653 Koreans enrolled ...

Diabetes mellitus (DM) has become an epidemic, causing a significant decline in quality of life of individuals due to its multisystem involvement. Kidney is an important target organ in DM accounting for the majority of patients requiring renal replacement therapy at dialysis units. Microalbuminuria (MA) has been a valuable tool to predict end-organ damage in DM but its low sensitivity has driv...

The Pattern of Nondipping and Urinary Albumin Excretion To the Editor: We read the article published recently by Oliveras et al1 with interest. The authors showed that, in resistant hypertensive patients, there were significant associations of microalbuminuria with older age, reduced estimated glomerular filtration rate, increased nighttime systolic blood pressure, and elevated daytime, nightti...

Protein restriction is used conventionally in the prevention and treatment of diabetic nephropathy. Recently, the use of soy protein instead of animal protein has been postulated as a new preventive and treatment option. The aim of this study was to determine the qualitative and quantitative effects of dietary protein on biomarkers of diabetic nephropathy in a Type 2 diabetes mellitus mouse mod...

Background: Gestational hypertension (BP ≥ 140/90 mm of Hg without proteinuria) is classified under hypertensive disorders of pregnancy (HDP). HDP causes widespread endothelial dysfunction leading to hypertension and damage to vital organs such as liver, kidney, brain etc. Damage to kidney may lead to elevation in urinary excretion of albumin which can be used for predicting severity of the dis...

The usefulness of bromcresol green for estimating albumin in urine was evaluated by comparison with the Laurell "rocket" technique. In contrast to the bromcresol green method applied for urinary albumin, rather doubtful results were obtained with conventional (Microzone) electrophoresis for albumin and with precipitation techniques for total protein estimation. Albumin estimation with bromcreso...

The screening for chronic kidney disease (CKD) patients needs the measurement of serum markers like creatinine. Our previous results indicated that urinary excretion of β-trace protein (BTP), a low-molecular-weight protein (23-29 kDa), is increased in CKD patients from stage 2. The aim of this study was to assess the major determinants of urinary excretion of BTP and to evaluate its feasibility...

Diabetes mellitus causes changes in metabolism of extracellular nucleotides acting through P2 receptors (P2Rs). This affects renal function and may lead to glomerular tubular disturbances. We measured urinary excretion (ATP, ADP, AMP, UTP, UDP, UMP) streptozotocin-induced diabetic rats (65 mg/kg, i.p., day 0) the effects P2Rs’ blockade by suramin (10 days +7, +14) on P2×7R expression (albumin, ...

BACKGROUND Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state ...