More than 380,000 new cases of bladder cancer are diagnosed worldwide, accounting for ∼150,200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, isobaric tags for relative and absolute quantitation labeling, and liquid chromatography-tandem MS (LC-MS/MS) analysis to profile proteomic changes in fresh-frozen bladder tumo...

More than 380,000 new cases of bladder cancer are diagnosed worldwide, accounting for 150,200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, isobaric tags for relative and absolute quantitation labeling, and liquid chromatography-tandem MS (LC-MS/MS) analysis to profile proteomic changes in fresh-frozen bladder tumor...

PURPOSE Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in polyamine homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating the clinical relevance of PMF1 methylation in bladder cancer. EXPERIMENTAL DESIGN The epigenetic silencing of PMF1 by hypermethylation was tested in b...

Platelet aggregation-inducing factor Aggrus, also known as podoplanin, is associated with tumor malignancy by promoting hematogenous metastasis. Aggrus overexpression has been reported in some tumor tissues including lung, esophagus, head and neck and brain. We here found the frequent upregulation of aggrus mRNA in urinary bladder cancers using cancer tissue panels from various organs. Immunohi...

OBJECTIVE Identify prognostic factors associated to late urinary toxicity in patients with prostate cancer submitted to radical conformal radiotherapy (3DCRT). MATERIALS AND METHODS From July 1997 to January 2002, 285 patients with localized prostate cancer were consecutively treated with 3DCRT and retrospectively analyzed. Thirty seven (13%) patients were submitted to transurethral prostate ...

Objectives: This paper explores the diagnostic and staging procedures available for bladder cancer, the prognostic factors for recurrence and progression of non-muscle-invasive tumours, and the indications for intravesical therapy and cystectomy in patients with non-muscle-invasive, recurrent disease. Methods: The authors reviewed the literature on diagnosis of bladder cancer, prognostic factor...

The aim of the study was to investigate genetic polymorphism in apoptotic gene, BCL-2 (C938A), and the risk of bladder cancer through a hospital-based case-control study. This retrospective analysis consisted of 270 cases of bladder cancer and 252 controls. The BCL-2 938 AA genotype showed a decreased risk of bladder cancer among smokers (OR = 0.40, 95% CI = 0.19-0.85), hence, showing a protect...

one of the rarest tumors involving the urinary bladder is the pheochromocytoma. a case of pheochromocytoma of the urinary bladder in a young female suffering from headache and cystitis for many years is reported. twenty-four hour urine vma was normal. the patient was never hypertensive except during surgical manipulation of the tumor. biopsy of the bladder resulted in massive hemorrhage.

About 180,000 new cases of urinary bladder cancer are diagnosed each year in the European Union. The most relevant risk factors are occupational exposure to aromatic amines and cigarette smoking (Golka et al. Recently, genome-wide association studies have successfully identified several urinary bladder cancer susceptibility loci (review: it has been shown that several high risk alleles of singl...

BACKGROUND It is well known in the literature that imaging has almost no value for diagnosis of superficial bladder cancer. However, wide gap exists between knowledge on diagnosis of bladder cancer and actual clinical practice. CASE PRESENTATION Delay in diagnosis of bladder cancer in a male person with tetraplegia occurred because of reliance on negative flexible cystoscopy and single biopsy...