This study was conducted to evaluate the effectiveness of a combination of gemcitabine and nedaplatin therapy among patients with metastatic urothelial carcinoma previously treated with two lines of chemotherapy. Between February 2009 and August 2013, 30 patients were treated with gemcitabine and paclitaxel as a second-line chemotherapy. All had received a first-line chemotherapy consisting of ...

OBJECTIVE To evaluate the value of liquid-based cytology (LBC) in the diagnosis of urothelial carcinoma. METHOD Diagnostic studies were searched for the diagnostic value of LBC in urothelial carcinoma in PubMed, Embase, Cochrane Library, Web of Science, CBM and CNKI. The latest retrieval date was September 2014. The data were extracted and the quality of the included studies was independently...

AIMS To report on the clinicopathological features of 20 cases of microcystic urothelial bladder carcinoma. METHODS AND RESULTS The extent of microcystic component varied from 50-100% of the specimens. The cysts were round-oval and of varying sizes; the periphery of large cysts was frequently punctuated by many smaller cysts. The cysts were lined by urothelial, low columnar cells or by a sing...

Recent studies have shown that chromosome 9p21 locus is frequently deleted in the early stages of urothelial carcinogenesis. To study the predictive value of the 9p21 aberrations in recurrence of urothelial carcinoma of the urinary bladder, we applied dual-color fluorescence in situ hybridization for 9p21 and chromosome 9 centromere to the bladder washing cytology samples that were obtained fro...

Abstract Bladder cancer is the most common neoplasm of urinary system, and urothelial carcinoma histological type bladder (approximately 90%), represents invasion basement membrane or lamina propria by cells. Most people with have hematuria doctor should be consulted as soon possible a specialist scheduled to examine camera - cystoscopy. The present study retrospective that includes 174 patient...

Overexpression of CD24, a glycosyl phosphatidylinositol-linked sialoglycoprotein, is associated with poor outcome in urothelial carcinoma and contributes to experimental tumor growth and metastasis. However, the requirement for CD24 (Cd24a in mice) in tumorigenesis and spontaneous metastasis from the orthotopic site remains uncharacterized. Using N-butyl-N-(4-hydroxybutyl) nitrosamine induction...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. While restricted to less than 10% of the urothelial cell carcinoma spectrum, bladder micropapillary carcinoma (MPUC) is associated with shorter survival due to early and wide metastatic chemo resistant spread. Such ominous behavior makes it an interesting model to identify new diagnostic, prognostic, and therapeutic t...

Ik Joon Choi, Sung Hwan Jung, Won Ik Seo, Pil Moon Kang, Soo Jin Jung, Jae Il Chung From the Departments of Urology and Pathology, College of Medicine, Inje University, Busan, Korea The simultaneous occurrence of a renal cell carcinoma and a urothelial carcinoma in the same kidney is uncommon. Here we report the case of a 79-year-old woman with ipsilateral synchronous renal cell carcinoma and u...

Isolated adrenal metastasis of bladder cancer, particularly the bilateral, is quite rare. Systemic chemotherapy is the treatment of choice for metastatic urothelial carcinoma. However, despite initially promising response rates of approximately 45%-71%, most tumors eventually show progression, and the median survival time following chemotherapy regimen is approximately 14-15 months. Recently, f...