in this study, 16 eligible dogs were randomly divided in to 4 groups. group 1, 2, 3 and 4 received autoclaved leishmania infantum with bcg (ali+bcg), autoclaved leishmania major + bcg (alm + bcg), bcg alone and normal saline, respectively. dogs received the vaccines intradermally 3 times at 30 days intervals. all dogs were followed up 2 months intervals by leishmanin skin test and anti -leishma...

objective(s): soluble leishmania antigens (sla) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-a (pla) activity of sla is a drawback to prepare a stable liposomal sla. one strategy to overcome this problem might ...

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neisseria meningitidis is a major causative agent of bacterial septicemia and meningitis in humans. currently, there are no vaccines to prevent disease caused by strains of n.meningitidis serogroup b. the class 1 outer membrane protein (omp) has been named pora which is a cation selective transmembrane protein of 45 kda that forms trimeric pore in the meningococcal outer membrane. pora from ser...

  Humoral immune response of vaccine-I (supermatent from sonicated sporulated oocyst), vaccine –II (sediment from sonicated sporulated oocyst) and vaccine –III (un-sonicated sporulated oocyst) against conccidiosis in chickens was determined by indirect haemagglutination (IHA) test. IHA antibody titre was significantly higher (p

Background: Pneumococcal vaccine provides protection against invasive pneumococcal disease in population at risk. This study was conducted to compare the antibody response to 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in patients with thalassemia major. Methods: A randomized cross-over clinical trial was performed on 50 asplenic patients with t...

Haemorrhagic septicaemia (HS) vaccine which is prepared in Razi Institute is used in endemic areas ofIran. Aluminum-hydroxide gel was used as adjuvant for preparing this vaccine. Post-vaccinal shock reactionswere the main complaint after use of this vaccine. In a previous study, we could improve the vaccine byalum-precipitation Pasteurella multocida cells and removing the liquid phase. In this ...

this report describes the preparation of a safe and immunogenic single vaccine against capripox disease in sheep and goats using two different types of cells (primary lamb kidney and vero, a bovine turbinate cell line). this used the 0240 pox strain isolated from sheep during an outbreak. the prepared vaccine was administered subcutaneously and induced complete protection against an experimenta...