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Introduction: Various research works have reported elevated serum homocysteine levels with the use of antiepileptic drugs. This may lead to an increased risk atherosclerosis, a higher seizure frequency and also cause cognitive decline. Methods: Twenty five children (Two 12 years) on valproate monotherapy for more than one year same number age sex-matched healthy controls were enrolled. Venous b...

objective: to investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among iranian patients before and after sodium valproate treatment.   patients and methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. serum antinuclear antibodies (ana), anti-cardiolipin antibodies (acl), a...

objective: although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. it is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. there are controversies regarding sodium valproate efficacy in psychosis. although some studies have reported that it is effective in the ...

Increasing data suggest that impairments of cellular plasticity underlie the pathophysiology of bipolar disorder. In this context, it is noteworthy that AMPA glutamate receptor trafficking regulates synaptic plasticity, effects mediated by signaling cascades, which are targets for antimanic agents. The present studies were undertaken to determine whether two clinically effective, but structural...