OBJECTIVE To investigate the target cells and molecules with sodium valproate induced differentiation of human glioma cells. METHODS Nude mice bearing human glioma xenogenic graft subcutaneously were treated with sodium valproate. The expressions of HDAC1 and Tob genes of xenografts were analyzed with semiquantitative RT-PCR. The CD133+ cells (BTSCs) were isolated from glioma specimens by imm...

Plasma phenobarbitone concentrations and daily urinary excretion of phenobarbitone and its metabolites p-hydroxyphenobarbitone (conjugated and unconjugated), and [S]-phenobarbitone-N-glucoside were measured under steady-state conditions in two groups of epileptic patients, (i) taking phenobarbitone with or without other drugs, but not valproate (n = 12), and (ii) taking phenobarbitone with othe...

As the brand Epilim, there is a sugar free liquid and oral syrup both containing sodium valproate 200mg in 5ml. It is also available as sodium valproate 100mg crushable tablets, 200mg and 500mg enteric coated tablets and 200mg, 300mg and 500mg modified release tablets. There are also a number of these preparations available as generic formulations both of sodium valproate and valproic acid. It ...

Epilepsy is defined as the occurrence of two or more unprovoked seizures. The cumulative life time incidence is 3%, and more than half start in childhood. Antiepileptic valproic acid is used in most of the cases as 1 st line therapy. The objective of the study was to evaluate the effect of valproate on thyroid hormone, insulin and prolactin in childhood epilepsy. A hospital-based, analytical cr...

Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in ...

OBJECTIVE To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. METHODS Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2(nd), 4(th), 5(th), 7(th), 10(th) and 15(th) week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical ana...

Correspondence Sodium valproate and pregnancy Sir, We were presented with a baby born to a mother taking sodium valproate who wished to breast feed. There are no data on breast milk levels of sodium valproate; it is presumed from collateral evidence that some of the drug would pass across from maternal serum into the milk. Studies in animals given modest doses of sodium valproate during pregnan...

Repetitive exposure to methylphenidate (MPD) elicits sensitization to its locomotor effects. Drugs that affect the GABA system may modify adaptations to drug exposure. Therefore, we have examined the effect of sodium valproate, which enhances GABA function, on the development of sensitization to MPD using an automated, computerized animal activity monitoring system to record each rat's motor ac...