conclusions only a small number of case reports have described valproic acid-induced dress syndrome; therefore, the condition is difficult to prevent. rechallenge with valproic acid should be avoided in patients with a history of reaction to the drug. case presentation we report on the case of a 60-year-old man who had been treated with valproic acid some time before being referred to kowsar ho...

Histone deacetylase inhibitors (HDACi) are a promising class of anticancer agents, yet the specific biological effects resulting in cell death are still poorly understood and clinically relevant markers of response are not adequately defined. The anticonvulsant valproic acid has recently emerged as an HDACi, and in vitro studies suggested that valproic acid may potentiate cytotoxic agents. We e...

OBJECTIVE To observe clinical and laboratory features of valproic acid-induced hyperammonaemic encephalopathy in patients taking valproic acid. METHODS Observational study was conducted at the Neurology Department, Dow University of Health Sciences, Civil Hospital, Karachi, from February 26, 2010 to March 20, 2011. Ten patients on valproic acid therapy of any age group with idiopathic or seco...

objective(s) the purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (vpa) in bipolar patients in comparison with those of epileptic patients. materials and methods ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. blood samples were c...

a simple, reproducible and rapid gas chromatographic method for precise determination of valproic acid (vpa) in human plasma has been developed. total time for sample preparation and gc analysis is less than 45 min. after plasma protein precipitation, vpa was extracted into chloroform with suitable recovery. by using stabilwax®-da capillary gc column, a symmetrical gas chromatographic peak was ...

Introduction Valproic acid (Depakine ) is an anti-epileptic drug which is indicated for the treatment of primary generalized epilepsy, partial epilepsy, with focal and psychomotoric symptoms and secondary forms of generalized epilepsia. The mechanism of action of valproic acid has not yet been established, the activity may be related to increased brain concentrations of gamma-aminobutyric acid ...

Valproic acid is widely used as an anti-epileptic globally. Anti-epileptic action is mediated by Gamma Amino Butyric Acid (GABA) receptors. In past and recently, several other clinical outcomes have been proposed by various studies. These under-reported clinical actions apart from anti-epileptic activity are mediated by various intracellular and extracellular pathways. Several mechanisms like H...

background and objective: copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. previous studies have shown that copper sulfate () inhibits long-term potentiation (ltp) in slices of hippocampal ca1 region. whereas ltp is involved in learning and epilepsy, it seems that copper effects on ltp could be associated with its effect...

WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...

We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriat...