vascular disease diagnostic and therapeutic approaches peripheral vascular disease basic diagnostic and peripheral vascular disease basic diagnostic and peripheral vascular diseasebasic diagnostic and vascular disease diagnostic and therapeutic approaches vascular disease diagnostic and therapeutic approaches peripheral vascular disease: basic diagnostic and nanomedicine approaches in vascular ...

There is little doubt that one of the greatest advances in the field of peripheral arterial disease was our ability to visualize problems wherever they occurred. This was possible because of the development of arteriography. One of the dramatic developments that made this possible was the observation by Forsmann1 in 1929 that a catheter could be threaded through a peripheral vein into the right...

Correspondence to: Mr John H N Wolfe, Department of Vascular Surgery, St Mary’s Hospital, Praed Street, London W2 1NY, UK; john.wolfe@ st-marys.nhs.uk _________________________ T he recognition that atherosclerosis is a systemic process means that the fields of cardiology and vascular surgery frequently overlap. The cardiologist should have an understanding of the recent developments in the tre...

Background. This study was designed to evaluate the effect of severe peripheral arterial insufficiency on carnitine concentrations and carnitine acetyltransferase and palmitoyltransferase activities in the ischemic skeletal muscles of patients with severe peripheral vascular disease. Methds and Results. Nine biopsy specimens ofischemic muscles were obtained from five patients undergoing reconst...

We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

For more than 20 years, moderately raised concentrations of total homocysteine (tHcy) have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong and dose-related, and it is biological...

Long study of human post-mortem material and of the arterial disease in rabbits that follows cholesterol feeding has not yet resulted in an understanding of the pathogenesis of arteriosclerosis. Although the focal distribution of the lesions in man and the partition of their contained lipids suggest interactions of local and hemic factors, it has proven difficult to determine either the nature ...

Nitric oxide (NO) signaling pathways and lipid oxidation reactions are of central importance in both the maintenance of vascular homeostasis and the progression of vascular disease. Because both of these pathways involve free radical species that can also react together at extremely fast rates, convergent interactions between these pathways are expected. Biochemical and cell biology studies hav...

www.chestpubs.org CHEST / 141 / 4 / APRIL, 2012 923 P arterial hypertension (PAH) is a lifethreatening disease that may occur either in idiopathic form or in the setting of different associated medical conditions. PAH is characterized by a marked and sustained elevation of pulmonary vascular resistance, leading to an increase in pulmonary artery pressure, right ventricular failure, and ultimate...

Doctors Barnet and Fraser of the Alfred Hospital Clinical Research Unit, Melbourne, Australia submitted this monograph for the Stawell Memorial Prize Essay of the British Medical Association for the year 1952 and were awarded the prize. They believed a "fresh consideration" of peripheral vascular disease in order because of the great prevalence of this type of disease, the need for increasing a...