Using quin 2 microfluorometry of porcine vascular smooth muscle cells in primary culture at 25 degrees C, we investigated differences in cytosolic calcium transients between epicardial coronary artery and aorta. Both in coronary arterial and aortic smooth muscle cells, histamine induced transient and dose-dependent elevations of cytosolic calcium concentrations, with a similar time course and E...

introduction: we did this study because there were a few studies about aorto-branch junction. methods: four light microscope and electron microscope study, the abdominal aorta, renal artery, and the adjoining right and left renal arteries were dissected out from 4 neonate dogs. results: based on the results, there is only one cell type in the tunica intima of endothelium in both arteries. in ab...

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administ...

saffron, crocus sativus l. (c. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. these therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. the effect of c. sativus and its constituents on different smooth muscles an...

Vascular sympathetic neuroeffector associations have been examined in rat iris arterioles using serial section electron microscopy and reconstruction techniques. Examination of random sections showed that, of all profiles of varicosities (199) seen to lie closer than 4 microns to vascular smooth muscle cells, only a small proportion (29/199) were found in close association with vascular smooth ...

the purpose of this study was to gain more information on the structure of different layers of renal arteryand comparing these structures in post-natal male and female sheep. to do so, right and left renal arteries of6 adult and 6 newborn animals were dissected; the middle parts of arteries were only collected. after tissueprocessing using paraffin embedding method, 5–6-μm sections were cut and...

Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...