OBJECTIVES To assess the efficacy and the tolerability of gabapentin 900 mg/day compared to vitamin E for the control of vasomotor symptoms in 115 women with breast cancer. The secondary objective was to evaluate the effect of the treatments on the quality of sleep and other aspects of the quality of life. METHODS A hot flush diary was completed daily; sleep quality and other menopausal sympt...

TRPV1 (transient receptor potential, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding of certain lipophilic molecules but also by extracellular protons and physical stimuli such as heat or osmotic pressure changes. These nonselective cation channels are permeable to Na(+) and K(+) and are also very Ca(2+) permeable; in fact, TRPV1 is as Ca(2+) pe...

Purpose:The purpose of this secondary analysis was to explore the associations between the frequency of hot flashes and sleep disruptions experienced by post menopausal women with the diagnosis of breast cancer and received acupuncture treatments for hot flashes. Data Sources: Data were gathered for this secondary analysis from 47 African-American, Hispanic, and Caucasian women experiencing hot...

Purpose Hot flashes are a significant clinical problem for many women. Currently there are limited options to hormone replacement therapy as non-hormonal pharmacological agents are associated with only modest activity and many adverse side effects. Hypnosis is one mind-body therapy that seems particularly promising for treating hot flashes and was investigated in the present study. This study e...

Flash memory shows promise for use in storage devices for mobile computers. However, flash memory cannot be overwritten unless erased in advance. Erase operations are slow that usually decrease system performance, and consume power. For power conservation, better system performance, and longer flash memory lifetime, system support for erasure management is necessary. In this report, a non-updat...

OBJECTIVE To evaluate the effects of escitalopram 10-20 mg/day on menopause-related quality of life and pain in healthy menopausal women with hot flashes. STUDY DESIGN A double-blind, placebo-controlled randomized trial of escitalopram 10-20mg/day vs. identical placebo was conducted among 205 women ages 40-62 years with an average of ≥4 daily hot flashes recruited at 4 clinical sites from Jul...

Oestrogen therapy is the gold standard treatment for hot flushes/night sweats, but it and oestrogen/progestin are not suitable for all women. MPA (medroxyprogesterone acetate) reduces hot flushes, but its effectiveness compared with oestrogen is unknown. In the present study, oral oestrogen [CEE (conjugated equine oestrogen)] and MPA were compared for their effects on hot flushes in a planned a...

OBJECTIVE To evaluate in a 12-month, prospective, randomized, double-blind, placebo-controlled study whether pure administration of the phytoestrogen genistein (54 mg/d) might reduce the number and severity of hot flushes in postmenopausal women with no adverse effect on the endometrium. DESIGN A total of 389 participants met the main study criteria and were randomly assigned to receive the p...

Flash memory shows promise for use in storage devices for mobile computers. However, flash memory cannot be overwritten unless erased in advance. Erase operations are slow that usually decrease system performance, and consume power. For power conservation, better system performance, and longer flash memory lifetime, system support for erasure management is necessary. In this report, a non-updat...

OBJECTIVE To evaluated whether Paullinia cupana decrease number and severity of hot flashes in breast cancer survivors. METHODS This was a prospective phase II pilot study. We studied female breast cancer survivors who had completed the cancer treatment 3 months previously and who were experiencing at least 14 hot flashes per week. At least 9 of the 15 patients were required to have a decreas...