OBJECTIVE Experimental and clinical studies have suggested that intramyocardial bone marrow stem cell transplantation combined with coronary artery bypass grafting might improve left ventricular function in the setting of chronic ischemic heart disease. We therefore conducted a systematic review and meta-analysis of available publications regarding the efficacy and safety of intramyocardial bon...

conclusions the findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the vf occurrence in rat. complementary studies are needed to elucidate the involved mechanisms of this abnormality. results nandrolone, exercise, and their combination were associated with heart hypertrophy. exercise could prevent the incremental effect of nandrol...

stress-induced cardiomyopathy or takotsubo cardiomyopathy is a recently increasing diagnosed disease manifested by transient apical or mid left ventricular dilation and dysfunction. this sign is similar to acute myocardial infarction but without significant coronary artery stenosis. there are important and essential differences between takotsubo cardiomyopathy and acute myocardial infarction in...

background: preeclampsia is a condition observed during pregnancy and threatens the life of both mother and fetus. there are studies which suggest that preeclampsia play a major role in the left ventricular mass. the aim of this study is to compare the electrocardiographic changes in normal pregnant and preeclamptic women. methods: the studied groups consisted of 48 mild preeclamptic, 33 severe...

As an alternative to electronic pacemakers, we explored the feasibility of converting ventricular myocytes into pacemakers by somatic cell fusion. The idea is to create chemically induced fusion between myocytes and syngeneic fibroblasts engineered to express HCN1 pacemaker channels (HCN1-fibroblasts). HCN1-fibroblasts were fused with freshly isolated guinea pig ventricular myocytes using polye...

To determine whether the overload associated with myocardial infarction and ventricular failure in rats is coupled with activation ofDNA synthesis in the remaining left and right ventricular myocytes, flow cytometric analysis was performed on myocyte nuclei prepared from both ventricles 7 and 30 days after coronary occlusion. In addition, oral captopril was administered in separate groups of co...

BACKGROUND Ventricular tachyarrhythmias are characteristic of giant cell myocarditis, but their true incidence, predictors, and outcome are unknown. METHODS AND RESULTS Our work involved 51 patients with giant cell myocarditis (35 women) aged 52±12 years. Their medical records were reviewed for history, results of laboratory and imaging studies, and occurrence of serious cardiac events, inclu...

The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been attributed to protracted neurogenesis by outer radial glial cells in the outer subventricular zone, a region present in humans but not in rodents. The mechanisms of human outer radial glial cell generation are unknown, but are proposed to involve division of ventr...

there are many treatment modalities available to acutely terminate incessant ventricular tachycardia with variable success rates, but some cases tend to prove refractory to all of them. we report a 59-year-old woman presenting with incessant ventricular tachycardia. echocardiography revealed a large true apical aneurysm and severe left ventricular dysfunction. the arrhythmia was controlled in t...

AIMS Patients with sickle cell disease have significant morbidity and mortality. Pulmonary hypertension is suggested to be an important contributor but its nature and severity in these patients and how best to non-invasively assess it are controversial. We hypothesised that a high-output state rather than primary pulmonary vascular pathology may be the major abnormality in sickle cell disease. ...