Vibrational spectroscopy has continued use as a powerful tool to characterize ionic liquids since the literature on room temperature molten salts experienced the rapid increase in number of publications in the 1990's. In the past years, infrared (IR) and Raman spectroscopies have provided insights on ionic interactions and the resulting liquid structure in ionic liquids. A large body of informa...

Many problems of physical chemistry belong to the class of inverse problems, in which from known experimental data of the object we need to determine some of its properties based on a certain model connecting these properties with measured characteristics. Inverse problems typically lead to mathematical models that are not well-posed in the sense of Hadamard, i.e. to the ill-posed problems. Thi...

Fourier transform infrared difference spectroscopy (FTIR DS) has been widely used to study the structural details of electron transfer cofactors (and their binding sites) in many types of photosynthetic protein complexes. This review focuses in particular on work that has been done to investigate the A₁cofactor in photosystem I photosynthetic reaction centers. A review of this subject area last...

The results of infrared spectroscopic investigations into the band assignments, vibrational relaxation, and solvation dynamics of the common anti-tuberculosis treatment Isoniazid (INH) are reported. INH is known to inhibit InhA, a 2-trans-enoyl-acyl carrier protein reductase enzyme responsible for the maintenance of cell walls in Mycobacterium tuberculosis but as new drug-resistant strains of t...

We review the recent development of chiral sum frequency generation (SFG) spectroscopy and its applications to study chiral vibrational structures at interfaces. This review summarizes observations of chiral SFG signals from various molecular systems and describes the molecular origins of chiral SFG response. It focuses on the chiral vibrational structures of proteins and presents the chiral SF...

When my colleague Parvez Haris asked me to write a historical review on the evolution of biomedical vibrational spectroscopy I consented, but now I need to clarify what this review is about and what it is not. It is my personal belief that biomedical vibrational spectroscopy has yet to reach its full potential and therefore I will not restrict myself to recounting its past history but will look...

Vibrational modes of the relatively strongly bound H2He+ molecular ion and its deuterated congener D2He+ are investigated by low-resolution multi-photon photodissociation spectroscopy, using a combination 4 K cryogenic ion-trap machine free-electron-laser FELIX. The band origins obtained fully explained accurate variational calculations rovibrational states based on three-dimensional potential ...