Background and Aims: Influenza A viruses are important pathogens for humans especially in pandemic episodes. Two adamantane derivates, amantadine and rimantadine, are used for prophylaxis and treatment of influenza A virus infections. However, single amino acid substitutions in the M2 transmembrane domain which lead to amantadine resistance of these viruses occur at residues 26, 27, 30, 31 or 3...

objective: herpes simplex virus (hsvs) is a widespread human infectious agent, responsible for persistent and latent infections. herpes simplex virus infections are usually continually recurrent in the normal population and represent a significant cause of complications in immunocompromised patients. materials and methods: in this study hsvs were propagated in bk cells and more than 502 sample...

viruses are the most common causes of aseptic meningitis. early detection, treatment and management of viral meningitis are priority. this study aimed to evaluate common viral meningitis in children referred to taleghani pediatrics hospital in gorgan, south east of caspian sea, iran. in this descriptive study csf and blood samples were taken from 40 children with negative bacterial culture who ...

conclusions crs is a common disease with negative effects on the quality of patients’ lives. this study showed the high prevalence of these two common respiratory viruses in patients with crs. background chronic rhinosinusitis (crs) is one of the most common chronic illnesses, but the etiology and pathogenesis of crs are not well understood. few studies have been carried out on the role of viru...

abstract human blood and blood products is the source of a wide range of medicinal products used for the treatment and prevention of a variety of injuries and disease. despite stringent routine measures and filters employed, residual pathogen infectivity remains an important challenge in the field of blood transfusion. in this article various measures and technologies that can be applied in ord...

conclusions this study delineated the beneficial role of rsv for growth regulation of skin cancer cells and highlighted the involvement of rsv in the induction of apoptosis in a431 cells. these findings might conduct evidence into the oncolytic properties of rsv in the skin cancer. further studies are required to indicate intracellular targets for rsv-induced apoptosis in skin cancer cells. res...

alfalfa crops were surveyed for the incidence of alfalfa mosaic virus (amv), cucumber mosaic virus (cmv), peanut stunt virus (psv), bean leaf roll virus (blrv), bean yellow mosaic virus (bymv) and bean common mosaic virus (bcmv) in the major growing areas in the southeast and central regions of iran. samples were collected between may 2009 and march 2011 and analyzed for viral infection initial...

Sixteen avian influenza (AI) H9N2 viruses were isolated from disease outbreaks in different parts of Iranduring (1998–2001). These AI isolates were used for pathogenicity, haemagglutinin (HA) gene variation andphylogenetic analysis. Results in both pathogenicity tests and HA gene cleavage site sequence detectionrepresented a non-highly pathogenic feature for all Iranian AI isolates studied. The...

Background and Aims: The caspases are unique proteases that mediate the host cell apoptosis during viral infection. In this study, we identified the caspase cleavage motifs of H5N1 and H9N2 influenza viruses isolated during 1998-2012. Materials and Methods: Amino acid sequences of the eleven proteins encoded by the viruses as the caspase substrates downloaded from NCBI. The caspase cleavage mot...