A patient with recurrent pulmonary abscess, weight loss, and alcoholism was found to have extremely high serum vitamin B12 and unsaturated vitamin B12-binding capacity (UBBC) levels. While transcobalamin (TC) II was also increased, most of his UBBC was due to an abnormal binding protein which carried greater than 80% of the endogenous vitamin B12 and was not found in his saliva, granulocytes, o...

There has been considerable debate on the ability of Lactobacillus reuteri to produce the active form of vitamin B12. In this study, we demonstrated the ability of two wild type strains of Lactobacillus reuteri to produce α-(5,6-dimethylbenzimidazolyl)-cobamidcyanide or cyanocobalamin which are the active form of vitamin B12. This was possible by supplying the required compounds of vitamin B12,...

To assess the serum folate and vitamin B12 status in healthy Iranian adults, we designed a population-based cross-sectional study of 1200 individuals aged 20-80 years. Finally 984 participants (507 men and 477 women) were assessed. The mean serum folate was 4.61 (SD 2.40) ng/mL and the mean serum vitamin B12 level was 265.6 (SD 170.9) pg/mL. Overall 1.0% were folate deficient and 25.8% had low ...

BACKGROUND Vitamin B12 deficiency is known to produce a variety of neuropsychiatric manifestations including peripheral neuropathy, subacute combined degeneration of the spinal cord, optic atrophy, dementia, psychosis and mood disturbances. This case highlights seizures as yet another complication of vitamin B12 deficiency. Although unusual, this condition is nevertheless completely reversible ...

The usual dietary sources of Vitamin B12 are animal-derived foods, although a few plant-based foods contain substantial amounts of Vitamin B12. To prevent Vitamin B12 deficiency in high-risk populations such as vegetarians, it is necessary to identify plant-derived foods that contain high levels of Vitamin B12. A survey of naturally occurring plant-derived food sources with high Vitamin B12 con...

Methods for the determination of Vitamin B12 remain limited due to their low sensitivity and poor selectivity. In the present work, a simple and sensitive HPLC-ESI-MS method for determining Vitamin B12 in food products and in multivitamin-multimineral tablets was developed. Vitamin B12 was extracted from food products with 50 mM sodium acetate buffer (pH 4.0) in the presence of sodium cyanide. ...

BACKGROUND low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence of vitamin B12 deficiency in the absence of anaemia is uncertain. OBJECTIVE to examine associations of cognitive impairment, depression and neuropathy with blood measurements of vitamin B12 and folate status in older people. DESIGN cross-sectional study in general practic...

This study was aimed to investigate the vitamin B12 deficiency prevalence and symptoms in elderly people lived in a community of Shanghai, China. A total number of 962 elderly people resided in Shanghai community were recruited in the present study. They were 60 years and older, and the average age was 76.38 ± 13.68 years old. Information on previous and present diseases, currently prescribed a...

BACKGROUND Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. Given the lack of studies in frontotemporal dementia (FTD) and on folate and g...

BACKGROUND Vitamin B12 deficiency is associated with a wide spectrum of neuro-psychiatric manifestations. RESULTS We report a case of a 44 year old female patient referred to the haematology unit with vitamin B12 deficiency presenting as an acute confusional state or delirium. Total resolution of the psychiatric symptoms occurred following parenteral vitamin B12 replacement therapy. CONCLUS...