نتایج جستجو برای: vitiligo

تعداد نتایج: 3441  

2012
Naresh C. Laddha Mitesh Dwivedi Rasheedunnisa Begum

Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as abnormal immune responses have frequently been observed in vitiligo patients. Moreover, vitiligo patients show higher lesion levels of TNF-α. Genetic polymorphisms in the promoter region of TNF-α are involved in the regulat...

Journal: :Indian journal of dermatology, venereology and leprology 2007
K V T Gopal G Raghu Rama Rao Y Hari Kishan Kumar M V Appa Rao P Vasudev

BACKGROUND Recent clinical and animal experimental studies postulate that the pathogenetic mechanisms of vitiligo could be of systemic origin as vitiligo is associated with ocular and auditory abnormalities as well as other autoimmune disorders.Hence, we studied genetic factors, systemic associations, ocular and auditory abnormalities of vitiligo. METHODS The study group included 150 new case...

Journal: :Genetics and molecular research : GMR 2011
H Bulut M Pehlivan S Alper A G Tomatir H Onay S E Yüksel F Ozkinay S Pehlivan

Accumulation of hydrogen peroxide (H(2)O(2)) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping...

2017
Vasanop Vachiramon Sarawin Harnchoowong Woranit Onprasert Kumutnart Chanprapaph

Background Vitiligo is an acquired hypopigmentary disorder. The prevalence of vitiligo is 0.1-2% worldwide. Numerous autoimmune diseases are associated with vitiligo, including autoimmune thyroid diseases. The prevalence of thyroid abnormalities is up to 34% in vitiligo patients depending on ethnicities. Objective This study aims to investigate thyroid abnormalities in Thai patients with viti...

Journal: :Frontiers in genetics 2016
Changbing Shen Jing Gao Yujun Sheng Jinfa Dou Fusheng Zhou Xiaodong Zheng Randy Ko Xianfa Tang Caihong Zhu Xianyong Yin Liangdan Sun Yong Cui Xuejun Zhang

Vitiligo is an autoimmune disease with a strong genetic component, characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Genetic factors are known to play key roles in vitiligo through discoveries in association studies and family studies. Previously, vitiligo susceptibility genes were mainly revealed through linkage analysis and candidate gene studies. Recent...

2004
Renée Lengagne Frédérique-Anne Le Gal Marylène Garcette Laurence Fiette Patrick Ave Masashi Kato Jean-Paul Briand Christian Massot Izumi Nakashima Laurent Rénia Jean-Gérard Guillet Armelle Prévost-Blondel

Tumor antigen-reactive T cells can be detected in a large proportion of melanoma patients, but their efficacy on tumor control in vivo remains unclear. On the other hand, vitiligo, a skin disorder characterized by patchy depigmented macules, may occur spontaneously or after antitumor therapies. Moreover, vitiligo is significantly associated with positive clinical response, but the mechanism is ...

Journal: :international journal of preventive medicine 0
zabihollah shahmoradi jamshid najafian farahnaz fatemi naeini farinaz fahimipour

background: vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. the exact etiology and pathogenesis of vitiligo is not clear. many theories have been presented regarding this subject among them aautoimmune theory is the most important one. the association of vitiligo with other autoimmune disorders has been reported, but the relationship ...

2017
Vasanop Vachiramon Woranit Onprasert Sarawin Harnchoowong Kumutnart Chanprapaph

OBJECTIVE Vitiligo usually presented as asymptomatic depigmented macules and patches. Little is known regarding itch in vitiligo. This study aimed to evaluate the prevalence and characteristics of itch in vitiligo patients. PATIENTS AND METHODS A cross-sectional study was conducted on vitiligo patients. Itch character and intensity were determined through questionnaires. Evaluation was also m...

Journal: :Cancer research 2004
Renée Lengagne Frédérique-Anne Le Gal Marylène Garcette Laurence Fiette Patrick Ave Masashi Kato Jean-Paul Briand Christian Massot Izumi Nakashima Laurent Rénia Jean-Gérard Guillet Armelle Prévost-Blondel

Tumor antigen-reactive T cells can be detected in a large proportion of melanoma patients, but their efficacy on tumor control in vivo remains unclear. On the other hand, vitiligo, a skin disorder characterized by patchy depigmented macules, may occur spontaneously or after antitumor therapies. Moreover, vitiligo is significantly associated with positive clinical response, but the mechanism is ...

2017
Hui Zhou Liang-Cai Wu Mu-Kai Chen Qi-Man Liao Ren-Xiang Mao Jian-De Han

BACKGROUND Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients. METHODS We performed a retrospective study on consecutive patient...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید