OBJECTIVE To determine whether the extent, distribution, and duration of vitiligo are associated with impairment of specific aspects of quality of life. DESIGN A prospective questionnaire-based study of 1541 adults with vitiligo. SETTING Online questionnaire. MAIN OUTCOME MEASURES Affected body surface area (BSA), distribution and duration of vitiligo, associated symptoms, and quality of ...

tyrosinase has been recognized as a major autoantign in human vitiligo. here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete freund’s adjuvant in c57bl/6 mice. the onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. our results con...

BACKGROUND Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis. AIM To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo. METHODS Nineteen patients with limited v...

The impact of vitiligo on quality of life is controversial. The aim of this study was to observe the impairment of quality of life and emotional state in adults with vitiligo compared with subjects with psoriasis and unaffected controls. The study group comprised 54 subjects with vitiligo, 57 with psoriasis and 57 unaffected controls. All subjects were examined and interviewed using the Dermato...

I read with interest and appreciated the paper of Kiniwa et al. (1), which was published in a recent issue of Cancer Research. They identified a novel melanoma/melanocyte antigen (KU-MEL-1), isolated from a patient with vitiligo and T-cell-infiltrated metastatic melanoma, that induced IgG responses in patients with various cancers and Vogt-Koyanagi-Harada disease but did not in 12 vitiligo pati...

OBJECTIVES Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health informat...

PURPOSE Vitiligo is an acquired pigmentary skin disease that can cause serious cosmetic problems. There have been numerous and well established studies that have demonstrated the comorbidity of various psychiatric disorders in patients with vitiligo. However, to our knowledge, there have been no studies investigating whether a psychiatric biomarker, such as brain-derived neurotrophic factor (BD...

BACKGROUND Vitiligo affects melanocytes in the skin. Since melanocytes are present in other organs as well, it is plausible that they may be similarly affected. METHODS A comparative study of audiological functions was carried out in 180 patients of vitiligo and 60 non-vitiligo controls in the age group of 5-40 years. RESULTS In vitiligo patients sensorineural hypoacusis of mild degree was ...

Objective To determine the familial frequency of vitiligo and its association with autoimmune disorders. Methods This cross-sectional study was conducted in the Department of Dermatology, Mayo Hospital, Lahore. Hundred patients of vitiligo of any age and either sex, diagnosed on the basis of history and clinical examination were enrolled from the outpatient department. Patients were evaluated f...

Vitiligo is a mucocutaneous pigmentary disorder with worldwide distribution. Little is known about the clinical profile of vitiligo in North-eastern China. Accordingly, we reviewed 692 vitiligo out-patients from seven government hospitals in North-eastern China via a questionnaire in a multi-centre study conducted between June 2007 and June 2008, and hence characterized the epidemiology of viti...