vitiligo is a disease that results in depigmented areas in the skin. it may develop at any age but the average age at onset is 20 years. association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. we report a 73‑year‑old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following ye...

Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childh...

BACKGROUND Vitiligo is considered the most frequent acquired hypomelanosis. Although its pathogenesis is uncertain, it is believed that autoimmune etiology is the most plausible. This theory is based on the coexistence of vitiligo with autoimmune diseases. OBJECTIVES To describe the epidemiological profile of vitiligo patients and to estimate the prevalence of the association of vitiligo with...

BACKGROUND Vitiligo is a chronic, common disease of unknown etiology, and oxidative stress is suggested to have a role in its etiopathogenesis. OBJECTIVE Advanced oxidation protein products (AOPPs), prooxidant-antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were evaluated regarding their role in the pathogenesis of vitiligo as well as their relationship with clinical p...

Vitiligo is an acquired depigmentary skin disorder characterized by white maculae on the skin associated with social stigma. Vitiligo has major impact on the quality of life due its high cosmetic value, chronic nature of disease and long term ineffective treatments. Vitiligo patients suffer from low self-esteem and poor body image that affects their emotional and psychological well-being. To in...

INTRODUCTION Vitiligo is an acquired idiopathic depigmentary disorder, which, though worldwide in distribution, is very common in India, Egypt and other tropical countries. While patients become desperate, develop a complex and social ostracism, a conscientious physician feels guilty because of his limitations. Though various aspects of vitiligo have been extensively studied, its etiopathogenes...

BACKGROUND Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function abnormalities. METHODS A retrospective chart review was performed on 333 children who had been f...

Vitiligo is an acquired skin disorder characterized by patchy depigmentation of the skin [1]. Vitiligo affects approximately 0.5% to 2% of the population worldwide, and the prevalence appears to be equal between men and women [2,3]. The pathogenesis of vitiligo is still not fully understood and mounting evidences have suggested that it might be related to autoimmunity and oxidative stress [4]. ...

Vitiligo is a complex genetic skin depigmentation disorder caused by the destruction of melanocyte from the lesional site. Liver X Receptor-α (LXR-α) expression is upregulated in the melanocytes from perilesional skin as compared to the normal skin of vitiligo patient suggesting its involvement in vitiligo pathogenesis. Polymorphisms in LXR-α have been associated with several diseases including...

BACKGROUND It was previously thought that persons with genetic predispositions to vitiligo develop the condition after exposure to various precipitating environmental factors. However, in many cases, the aggravating factors of vitiligo have not been clearly identified. OBJECTIVE To identify the aggravating factors of vitiligo in the working environment and daily life. METHODS A total of 489...