The activity of the epithelial Na(+) channel (ENaC) is required for the maintenance of salt and water balance in the body. Channel activity is regulated by the ubiquitin-protein ligase Nedd4 ['neuronal precursor cell-expressed developmentally down-regulated (gene 4)'] that interacts with the channel via its WW domains. Mutations in channel subunits that disrupt this interaction cause Liddle's s...

Some producers in the inland Pacific Northwest (PNW) are interested diversifying traditional 2-yr sequence of winter wheat (Triticum aestivum L.) (WW)–summer fallow (SF) with oilseed crops to capture break crop effects. The objective this study was compare production costs and economic returns sequences those intensified 3-yr at a low-precipitation (<300 mm) site where long-term rotation has be...

We present recent diboson production measurements from the D0 experiment at Fermilab's Teva-tron collider. The production of ZZ was observed using leptonic final states. Zγ → ννγ was observed and used to set the most stringent limits from a hadron collider on anomalous Zγγ and ZZγ trilinear gauge couplings (TGCs). WW events with leptonic final states and WW +W Z events with semi-leptonic final ...

7 n 2  ≤ WW (G1) + WW (G2) + WW (G3) ≤ 2  n + 2 4  + n 2  + 4(n − 1). The corresponding extremal graphs are characterized. Published by Elsevier B.V.

Because of the association of beta-sheet formation with the initiation and propagation of amyloid diseases, model systems have been sought to further our understanding of this process. WW domains have been proposed as one such model system. Whereas the folding of the WW domains from human Yes-associated protein (YAP) and Pin have been shown to obey single-exponential kinetics, the folding of th...

AIMS To assess the impact of winery wastewater (WW) on biological sand filter (BSF) bacterial community structures, and to evaluate whether BSFs can constitute alternative and valuable treatment- processes to remediate WW. METHODS AND RESULTS During 112 days, WW was used to contaminate a BSF mesocosm (length 173 cm/width 106 cm/depth 30 cm). The effect of WW on bacterial communities of four B...

WW domains are conserved protein motifs of 38-40 amino acids found in a broad spectrum of proteins. They mediate protein-protein interactions by binding proline-rich modules in ligands. A 10 amino acid proline-rich portion of the morphogenic protein, formin, is bound in vitro by both the WW domain of the formin-binding protein 11 (FBP11) and the SH3 domain of Abl. To explore whether the FBP11 W...

WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine-proline sites. To pursue the functional properties of WW domains, we employed mass spectrometry to identify 148 proteins that associate with 10 human WW domains. Many of these proteins represent novel WW domain-binding partners and are c...