To interrelate in vivo wall shear stress, endothelial microfilament bundle formation, and atherosclerosis localization, we used a mild abdominal aortic stenosis in 11 beagles to produce a range of wall shear stresses above and below the constriction. Six of the beagles were fed standard animal chow supplemented with 5% cholesterol and 10% coconut oil. Wall shear stresses, endothelial microfilam...

BACKGROUND AND PURPOSE Aortic stenosis, causing flow abnormalities, disturbs the normal hemodynamics in the common carotid arteries. The aim of the present study was to investigate the remodeling process of the common carotid arteries after surgical correction of aortic stenosis. METHODS Eleven subjects with aortic stenosis were studied before and 1 and 6 months after aortic valve replacement...

Cross correlations of the fluctuating wall-shear stress and the streamwise velocity in the logarithmic region of turbulent boundary layers are reported over 3 orders of magnitude change in Reynolds number. These results are obtained using hot-film and hot-wire anemometry in a wind tunnel facility, and sonic anemometers and a purpose-built wall-shear stress sensor in the near-neutral atmospheric...

INTRODUCTION The onset of atherosclerosis may be related to changes in vascular endothelial permeability to macromolecules, which may in turn be induced by wall shear stress or its related indices. We report here an initial experiment that correlates, site-by-site, the albumin uptake in a porcine aortic trifurcation with several measures of wall shear obtained by computational fluid dynamic (CF...

BACKGROUND Unlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences in left ventricular wall shear stress and their association with endocardial endothelial cell gene expression. METHODS AND R...

PURPOSE The precise role played by hemodynamics, particularly wall shear stress, in the development and progression of vascular disease remains unclear, in large part because of a lack of in vivo studies with humans. Although technical challenges remain for noninvasively imaging wall shear stresses in humans, vascular anatomy can be imaged with sufficiently high resolution to allow reconstructi...

Abdominal Aortic Aneurysm is a potentially life-threatening disease if not treated adequately. Its pathogenesis is complex and multifactorial and is still not fully understood. Many biochemical and biomechanical mechanisms have been identified as playing a role in the formation of aneurysms but it is as yet unclear what triggers the process. We investigated the role of the relevant biomechanica...