The "traumatic degeneration" of peripheral nerves has been described by Ram6n y Cajal (16) as representing the alteration of both myelin sheath and axon in the central stump of a damaged nerve, in contrast to Wallerian degeneration in the distal part of the same nerve. Distal nerve degeneration and subsequent regeneration after mechanical injuries of peripheral nerve bundles have been well-docu...

We report the case of a patient with bilateral and symmetrical T2 hyperintensities of the middle cerebellar peduncles. She had a history of left pontine infarction 8 months before. This was attributed to bilateral Wallerian degeneration. MR Spectroscopy showed decreased N-acetyl aspartate/Creatine (NAA/Cr) ratio in the cerebellar peduncles as well as in the whole cerebellum. We hypothesize that...

A 57-year-old man was admitted to our clinic because of speech and swallowing disorder for six months. Palatal tremor and left upper extremity myorhythmia appeared on examination. Magnetic resonance imaging showed hypertrophic olivary degeneration, dentate pathology, Wallerian degeneration, and left parietal cystic encephalomalacia. Functional magnetic resonance imaging study of the brain showe...

(1000mgat days0 and 14). She continued to experienceworseninglowerextremityweakness.Eventually,shereceived6plasmapheresis treatments withminimal improvement. During the entire periodof follow-up at our center, she required 20 to 30mg daily of oral prednisone. Neurological examination prior to the onset of HiCy therapy revealed symmetrically reduced arm abduction (4−/5) and hip flexion strength ...

The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration. c-Jun governs major aspects of the injury response, determines the expression of trophic factors, adhesion molecules, the formation of regeneration tracks and m...