Address for correspondence: Dr. Kamble Jayaprakash Harsha, Department of Clinical Neurosciences, Brain and Spine Centre, Indo‐American Hospital, Chemmanakary ‐ 686 143, Vaikom, Kerala, India. E‐mail: [email protected] result of degradation and disintegration of myelin sheath. The T2/FLAIR hypointensity of corticospinal tracts during Wallerian degeneration was initially demonstrated by Kuhn et ...

After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve regeneration. This phenotype-changing process can be viewed as Schwann cell dedifferentiation. Here, we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation i...

A 46-year-old man presented with behavioral changes and partial seizures over 20 days. Neurological examination showed mental confusion. Brain MRI showed a ringshaped lesion in the left frontal lobe (A and B). Surgery was performed (C) and pathology confirmed glioblastoma multiforme. The patient underwent radiotherapy and che motherapy. A control MRI (eight months later) showed hyperintense sig...

Studies of naturally occurring mutant mice, wld(s), showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process. We previously showed that increased nicotinamide adenine dinucleotide (NAD)-synthesizing activity by overexpression of nicotinamide mononucleotide adenylyltransferase (NMNAT) is the essential component of the Wld(s) protein, the expression ...

Degeneration of the myelin sheath and axon distal to the most proximal site of axonal interruption secondary to axonal disease has been called wallerian degeneration. On MR imaging, wallerian degeneration of the pyramidal tract can be observed as an abnormal signal intensity, showing prolonged T1 and T2 relaxation times that correspond to the corticospinal tract, with or without shrinkage of th...

The NAD-synthesising enzyme Nmnat2 is a critical survival factor for axons in vitro and in vivo. We recently reported that loss of axonal transport vesicle association through mutations in its isoform-specific targeting and interaction domain (ISTID) reduces Nmnat2 ubiquitination, prolongs its half-life and boosts its axon protective capacity in primary culture neurons. Here, we report evidence...

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...