The clinical experience following transplantation of livers obtained from non-heart-beating cadaver donors (NHBD) with the use of core cooling method is presented here. Six livers procured from such cadavers were transplanted into 6 recipients with hepatoma involving right and left lobes but without distant metastases. The first liver subjected to 75 minutes of warm ischemia had insufficient fu...

The aim of the study was to assess the impact of the intermittent cold-blood cardioplegia (ICBC) on myocardial acidosis in comparison to the warm-blood cardioplegic administration (IWBC) in patients undergoing coronary bypass surgery. In 15 patients undergoing elective bypass surgery with ICBC for myocardial protection, metabolic changes of global ischemia indicators with lactate and pH values,...

Ischemia-reperfusion injury is a serious problem which can occur during lung transplantation. Preservation of pulmonary function by reducing ischemia-reperfusion injury is essential for successful lung transplantation. Although the mechanisms responsible for ischemia-reperfusion lung injury are not clear yet, it is commonly accepted that ischemic time, storage conditions and additive usage of s...

Apoptosis plays an important role in liver ischemia and reperfusion (I/R) injury. However, the molecular basis of apoptosis in I/R injury is poorly understood. The aims of this study were to ascertain when and how apoptotic signal transduction occurs in I/R injury. The apoptotic pathway in rats undergoing 90 min of warm ischemia with reperfusion was compared with that of rats undergoing prolong...

BACKGROUND/AIMS Atrial natriuretic peptide (ANP) protects against hypoxia/reoxygenation-induced damage of cultured hepatocytes, thus suggesting a therapeutic potential in the liver. Therefore, the effects of ANP on hepatic ischemia/reperfusion injury after warm ischemia were studied. METHODS Livers of male Sprague-Dawley rats subjected to 60 minutes of warm ischemia at 37 degrees C were perfu...

OBJECTIVE Ions, particularly calcium ions, play an important role in ischemia-reperfusion cell injury. In this study, we investigated the action of verapamil on the mitochondrial function of kidneys submitted to ischemia without blood reperfusion in order to study isolated early and late ischemic effects. MATERIALS AND METHODS 44 rats were submitted to bilateral warm renal ischemia for 30 min...

Liver grafts suffer from unavoidable injury due to ischemia and manipulation before implantation. Danger signals such as high-mobility group box -1(HMGB1) and macrophage migration inhibitory factor (MIF) play a pivotal role in the immune response. We characterized the kinetics of their release into the effluent during cold/warm ischemia and additional manipulation-induced mechanical damage. Fur...

In an era with robotic partial nephrectomy dominating as the predominate modality to tackle small renal masses, Choiand Bae (1) demonstrate that advanced laparoscopic skill in urology is still alive and well. The difficulty in management with multiple renal tumors is not only nephron preservation, but how to limit the amount of warm ischemia when having to preform multiple resections and renorr...