Lx2-32c is a novel taxane derivative with a strong antitumor activity. In this study, we developed Lx2-32c-loaded polymeric micelles (Lx2-32c-PMs) with small size and investigated their antitumor efficacy against tumor growth and metastasis on 4T1 murine breast cancer cell line with Cremophor EL-based Lx2-32c solution as the control. In this study, copolymer monomethoxy polyethylene glycol2000-...

Background & Aims: Studying about background radiation is important because human beings are continuously exposed to these radiations which leave energy in tissues and the transferred energy leads to undesirable biologic effects. The level of background radiation differs in indoor and outdoor places. Since, people spend more time indoors, in this research environmental gamma dose rate for indoo...

Lx2-32c is a novel taxane that has been demonstrated to have robust antitumor activity against different types of tumors including several paclitaxel-resistant neoplasms. Since the delivery vehicles for taxane, which include cremophor EL, are all associated with severe toxic effects, liposome-based Lx2-32c has been developed. In the present study, the pharmacokinetics, biodistribution, antitumo...

The relative DNA content of Manduca sexta abdominal epidermal nuclei during the final larval instar was measured by cytophotometry of whole-mount preparations of the epidermis. In the middle intrasegmental region, epidermal cells showed a ploidy level of 4C to 32C on the day of ecdysis. During the subsequent period of feeding, the proportion of higher ploidy cells, such as 16C and 32C, increase...

sustainable and energy efficient design issues are key to the way good buildings are designed in the 21st century. no building designer today should be without the basic skills offered by the unique multidisciplinary studies of architectural design, based on energy use in buildings. however, this paper is focusing of effect of air movement on human comfort, as a key element of building design. ...

Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32c was cytotoxic to al...

Thermal comfort under non-steady-state conditions primarily deals with rapid environmental transients and significant alterations of the meteorological conditions, activity, or clothing pattern within the time scale of some minutes. In such cases, thermal history plays an important role in respect to time, and thus, a dynamic approach is appropriate. The present study aims to investigate the dy...

Air conditioners are commonly used to keep electronics cool in various areas, such as industrial automation, telecommunication equipment, security and defense systems as well as other indoor and outdoor electronics applications. The electronics may be housed in protective enclosures, where air conditioners deliver cooled air to keep the entire enclosure at desired temperatures for optimum elect...

We show, using lattice models of proteins, how the kinetic accessibility of the native state of proteins is encoded in the primary sequence itself. The folding times for various sequences correlate extremely well with the single parameter intrinsic to the sequence, namely, s ­ jTu 2 Tf jyTu where Tu and Tf are the collapse and folding transition temperatures. Fast folding sequences have small v...