Obesity and the metabolic syndrome (MetS) are risk factors for left ventricular diastolic dysfunction (LVDD). However, little is known about the impact of successful weight reduction (WR) on diastolic function and physical performance.Obese subjects (øBMI 40.2 ± 8.6 kg/m(2)) underwent a 1-year WR program comprising diet and lifestyle components. Echocardiography and exercise capacity (6-minute ...

The vaccinia virus strain Western Reserve (WR) A34R gene encodes a C-type lectin-like glycoprotein, gp22-24, that is present in the outer membrane of extracellular enveloped virus (EEV) with type II membrane topology (S.A. Duncan and G.L. Smith, J. Virol. 66:1610-1621, 1992). Here we that a WR A34R deletion mutant (WR delta A34R) released 19- to 24-fold more EEV from infected cells than did WR ...

The kinematic structure of a sample of planetary nebulae, consisting of 23 [WR] central stars, 21 weak emission line stars (wels) and 57 non-emission line central stars, is studied. The [WR] stars are shown to be surrounded by turbulent nebulae, a characteristic shared by some wels but almost completely absent from the non-emission line stars. The fraction of objects showing turbulence for non-...

Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]5 and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl4 and the peptide generated peptide-capped gold nanoparticles. Here, [WR]5 and [WR]5-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow c...

Context. The favoured progenitors of long-duration gamma-ray bursts (GRBs) are rapidly rotating Wolf-Rayet (WR) stars. However, most Galactic WR stars are slow rotators, as stellar winds are thought to remove angular momentum. This poses a serious challenge to the collapsar model. Recent observations indicate that GRBs occur predominately in low metallicity (Z) environments, which may resolve t...

The waste-recycling Monte Carlo (WR) algorithm, introduced by Frenkel, is a modification of the Metropolis-Hastings algorithm, which makes use of all the proposals, whereas the standard Metropolis-Hastings algorithm only uses the accepted proposals. We prove the convergence of the WR algorithm and its asymptotic normality. We give an example which shows that in general the WR algorithm is not a...

BACKGROUND: The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin and streptavidin. Thus, a non-toxic tumor cell specific antibody is conjugated with avidin/streptavidin, and is administered to patients. After the antibody binds to tumor cell...

We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kernel pericarp and red cobs, whereas Ufo1 modifies P1-wr expression to confer pigm...