A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 with respect to base sequence is studied. The results obtained elucidate the origin of the preferenc...

Vasoconstrictive and Angiogenic Properties , a Novel Hypoxia-Induced Mitogenic Factor in Lung With α FIZZ1/RELM Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000073999.07698.33 2003;92:1065-1067;...

We studied the effect in vitro of various concentrations of Triton WR-1339 on normolipidemic canine plasma and on the high density lipoproteins (HDL) isolated from this plasma by ultracentrifugation. As a preamble to this study, we established that Triton WR-1339 has a unimer molecular weight of 4,500, a micellar molecular weight of 180,000, and a critical micellar concentration (CMC) of 0.018 ...

Hypocalcemia has been observed in patients receiving WR-2721 IS-,2-(3-aminopropylamino)-, ethylphosphorothioic acid]. WR2721 is a compound that, after being dephosphorylated, provides protection of normal tissues against radioand chemotherapy. The hypocalcemic response was accompanied by a decrease in the plasma level of parathyroid hormone (PTH) and by hypomagnesemia. Our present studies in ra...

Colliding-wind binaries (CWBs) constitute an emerging class of γ -ray sources powered by strong, dense winds in massive stellar systems. The most powerful them are those hosting a Wolf-Rayet (WR) star. Following the recent discovery Apep – closest known Galactic WR–WR binary we discuss non-detection its putative high-energy emission Fermi Large Area Telescope ( -LAT) this Letter. limits reporte...

CC-1065 is a very potent antitumor antibiotic which selectively binds in the minor groove of DNA with alkylation at N-3 of adenine. Since therapeutic doses of CC-1065 caused delayed deaths in mice, analogues were synthesized, some of which had significant antitumor activity. The effects of several of these analogues on inhibition of CHO cell survival, cell progression, and their phase-specific ...

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BACKGROUND There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. METHODS This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout...

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