Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At thes...

STUDY DESIGN Retrospective cohort. OBJECTIVE To explore the ability to capture low back pain (LBP) recurrence using wage-replacement (WR) data. SUMMARY OF BACKGROUND DATA LBP can be a recurrent, fluctuating, and disabling condition. Because of its largely nonspecific and subjective nature, the condition poses challenges for research and clinical management, as speaking directly with the aff...

PURPOSE Subjective push-up tests and dynamic retinoscopy are standard clinical accommodation tests. These are inadequate for assessing if accommodation can be restored in presbyopes. Commercially available clinical autorefractors offer potentially reliable methods for objective accommodation measurement. This study evaluated accuracy and reliability of the Grand Seiko WR-5100K autorefractor for...

New NTT/EMMI spectrophotometry of single WN2–5 stars in the Small and Large Magellanic Clouds are presented, from which He  λ4686 line luminosities have been derived, and compared with observations of other Magellanic Cloud WolfRayet stars from the literature. SMC WN3–4 stars possess line luminosities which are a factor of 4 times lower than LMC counterparts, incorporating several binary SMC ...

A 2 x 2 factorial study evaluated effects of cow wintering system and last trimester CP supplementation on performance of beef cows and steer progeny over a 3-yr period. Pregnant composite cows (Red Angus x Simmental) grazed winter range (WR; n = 4/yr) or corn residue (CR; n = 4/yr) during winter and within grazing treatment received 0.45 kg/d (DM) 28% CP cubes (PS; n = 4/yr) or no supplement (...

A previous analysis of World Records (WR) has revealed the potential limits of human physiology through athletes' personal commitment. The impact of political factors on sports has only been studied through Olympic medals and results. Here we studied 2876 WR from 63 nations in four summer disciplines. We propose three new indicators and show the impact of historical, geographical and economical...

The objective of this study was to validate use of the washed rumen (WR) technique for rapid measurement of fasting heat production (HP) and respiratory quotient (RQ). Sixteen Holstein steers were divided into 2 groups of 8 for a comparison of measurements made during feeding (both groups; 16 steers) and fasting (8 steers; BW = 237 ± 17 kg) and using the WR model (8 steers; BW = 322 ± 30 kg). S...

OBJECTIVE The physiology of the weight-reduced (WR) state suggests that pharmacologic agents affecting energy homeostasis may have greater efficacy in WR individuals. Our aim was to establish a protocol that allows for evaluation of efficacy of weight maintenance agents and to assess the effectiveness of AZD2820, a novel melanocortin 4 receptor (MC4R) agonist in such a paradigm. METHODS MC4R ...

This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while ...