Background Xenotransplantation of ovary can help individuals who may be at sterility risk after chemotherapy or radiotherapy of diseases such as cancer. Moreover, this technique can be used to preserve fertility of valuable animal species. The aim of the present study was to preserve balb/c mice ovarian tissue by xenotransplantation into uterus of rat that is immune suppressed. MaterialsAndMeth...

9.1 A health care system is part of a wider social order. Developments in health care cannot, therefore, be separated from their social context and the broader effects they may have. It is difficult to predict how social attitudes and institutions will respond to xenotransplantation, should it become introduced as a clinical treatment. It is important to consider what these responses might be, ...

Xenotransplantation, in particular the transplantation of pig cells, tissues and organs into human recipients, may alleviate the current shortage of suitable allografts available for human transplantation. This overview addresses the physiological, immunological and microbial factors involved in xenotransplantation. The issues reviewed include the merits of using pigs as xenograft source specie...

This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 a...

The trial and error of the pioneering xenotransplant trials over the past three decades has defined the limitation of the species used. Success was tantalizingly close with the chimpanzee, baboon, and other primates. The use of more disparate species has been frustrated by the xenoantibody barrier. Future attempts at clinical xenotransplantation will be hampered by the consideration of the spec...

wileyonlinelibrary.com/journal/xen | 1 of 4 https://doi.org/10.1111/xen.12366 © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. In this issue of xenotransplantation, Scobie et al. commented on our recent production of PERVinactivated pigs using CRISPRcas9.1 Based on the data of our studies, we believe there is an unneglectable risk of pigtohuman PERV transmission. We would like ...

The induction of T cell tolerance is likely to play an essential role in successful xenotransplantation in humans. In this study, we show that porcine thymus grafts in immunodeficient mice support normal development of polyclonal, functional human T cells. These T cells were specifically tolerant to MHC Ags of the porcine thymus donor and responded to nondonor porcine xenoantigens and alloantig...

Solid organ transplantation has been, by most measures, a phenomenal success. Nonetheless, the field is plagued by extreme shortages of available organs from a very limited number of donors. One potential solution to this organ availability crisis is the use of animals as organ donors for humans (xenotransplantation). Though the concept remains theoretical, significant advances are being made i...

Background In vitro culturing and retransplantion of vitrified- warmed ovarian tissue are two ways to restore fertility after radiation or chemotherapy.This study aimed to evaluate the incidence of apoptosis in vitrified human ovarian tissue after warming, long term culturing and xenotransplantation by morphological analyses and apoptosis genes expression evaluation. MaterialsAndMethods We obta...

The discussion about the ethics of xenotransplantation seems to focus upon the benefits for individual patients and the potential risks for human society, in general, to contract a newly emerging retrovirus. In these risk-benefit considerations, the moral concern for the research animals involved appears to be absent. This is remarkable, because the presumed successful xenograft is not expected...