Pereira, Sheila M., and Begum, Almas (1971). Archives of Disease in Childhood, 46, 525. Failure of a massive single oral dose of Vitamin A to prevent deficiency. Preschool children maintained on low and moderate carotene diets were given a single oral dose of 50,000 jg vitamin A palmitate. On the low carotene diet, xerosis was observed in 8 weeks' time in the control group of children, and in 1...

We were concerned to read the recent article by Pennie et al. (7) on the misidentification of toxigenic Corynebacterium diphtheriae as a Corynebacterium sp. with low virulence in a child with endocarditis. The paper raises several issues relating to current methods for the microbiological diagnosis of diphtheria. Firstly, specific guidelines on laboratory diagnosis have been issued by the World...

INTRODUCTION AND OBJECTIVES Cetuximab and panitumumab are monoclonal antibodies that target the epidermal growth factor receptor (EGFR) in the treatment of metastatic colorectal cancer. Most patients develop a papulopustular rash, which may predict tumor response. We studied whether the other adverse cutaneous effects associated with these monoclonal antibodies are also clinical predictors of r...

Plasma Vitamin ‘A’ and carotene levels were estimated in 1036 apparently healthy subjects of various ages and socio-economic groups by dietary, clinical and biochemical methods. In adult population (15-50 ± yrs) Vitamin ‘A’ for men averaged (mean ± SE) 42.6 ± 1.5mcg% and carotene 56.9 ± 2.8 mcg%; for women the corresponding values were 38.27 ± 2.0 mcg% and 52.65 ± 2.5mcg%. Diet was generally lo...

Sorafenib is a multikinase inhibitor FDA-approved for the treatment of advanced renal cell and hepatocellular carcinoma. Dermatologic side effects include hand-foot skin reaction, facial and scalp erythema and desquamation, splinter subungual hemorrhages, alopecia, pruritus, xerosis, keratoacanthomas, and squamous cell carcinomas. We report sudden eruption of melanocytic nevi diffusely in a pat...

Sir, Cutaneous manifestations are frequently found in patients with chronic renal failure. They can be classified as specific disorders (e.g. perforating disorders, metastatic calcification, bullous dermatosis) or non-specific disorders (e.g. skin colour changes, pruritus, elastosis, equimosis, xerosis, uraemic frost, half and half nails). We report here an unusual association between an acanth...

A method is described for rapidly obtaining fresh extracts of microorganisms by percussion of the frozen cells. Filtrates giving the biuret reaction and yielding heavy precipitates upon the addition of acetic acid were obtained from the washed cells of cultures of yeast, hemolytic streptococcus, pneumococcus, B. coli, B. xerosis, B. dyphtheriae and the bacillus of bovine tuberculosis.

Abstract People in the developed countries are living longer. Geriatric dermatology is playing an increasingly important role as chances of developing skin-related problems increase with their ageing. Skin ageing induced by two main processes: intrinsic and extrinsic. Extrinsic caused environmental factors such sun exposure, smoking, alcohol consumption, air pollution, poor nutrition. Intrinsic...

Background In HIV-positive individuals clinicians observe a broad range of skin conditions like xerosis, tumours, rash and drug-induced exanthema as well as common skin infections caused by bacteria, fungi and viruses. Beyond this, some reports point out a higher incidence on atopic conditions like atopic dermatitis (AD), sinusitis, asthma and laboratory findings like hypereosinophilia and Hype...