BACKGROUND Salivary gland hypofunction and xerostomia are major complications following radiotherapy for head and neck cancer and may lead to debilitating oral disorders and impaired quality of life. Currently, only symptomatic treatment is available. However, mesenchymal stem cell (MSC) therapy has shown promising results in preclinical studies. Objectives are to assess safety and efficacy in ...

BACKGROUND To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy cont...

BACKGROUND AND PURPOSE MR imaging of the salivary glands has been applied to the diagnosis of Sjogren's syndrome; however, the diagnosis remains qualitative. We sought to establish and evaluate quantitative MR imaging criteria for the diagnosis of Sjogren's syndrome. METHODS MR imaging with a 47-mm microscopy coil was performed in 83 patients with xerostomia (55 patients with Sjogren's syndro...

One of the common side effects of antihistamine medicines is xerostomia (dry mouth). The current consensus is that antihistamine-induced xerostomia comes from an antimuscarinic effect. Although the effect of antihistamines on salivary secretion is both obvious and significant, the cellular mechanism whereby this happens is still unclear because of the lack of knowledge of histamine signaling in...

BACKGROUND Ginger and aloe vera are two medicinal herbs mostly used to produce mouthwash. This study aimed compare the effects of ginger mouthwashes on xerostomia in patients referred Bandar Abbas diabetes clinic (Iran). MATERIAL AND METHODS In this triple-blind clinical trial, three groups (n=35 each group) were studied. One group was given mouthwash, other control only normal saline. All 20 c...

Complaints of a dry mouth (xerostomia) and sialoadenitis are frequent side effects of radioiodine treatment in differentiated thyroid cancer (DTC) patients. However, detailed prospective data on alterations in salivary gland functioning after radioiodine treatment (131I) are scarce. Therefore, the primary aim of this study was to prospectively assess the effect of high-activity radioiodine trea...

Introduction: Radiation therapy is the main treatment method for head and neck cancers, which comprise 3–5% of all cancers. A major side effect of this treatment is complication of the parotid glands, i.e. xerostomia, which occurs at relatively low doses. This complication leads to mouth dryness which is the most common problem for head and neck cancer survivors. There are dif...

Background: Association of Addison's disease with connective tissue diseases such as scleroderma and Sjogren have been rarely reported. Anti-centromere antibody (ACA) has been associated with exocrine gland dysfunction in anti-Ro, anti-La negative Sjogren’s syndrome and may be one of the causes of xerostomia in community. The purpose of this article was to introduce a rare case of scleroderma-S...

ABSTRACT Objective: The aim of this study was to evaluate the relationship among following features: hyposalivation, systemic diseases and drug use, oral symptoms, dental condition, salivary flow pH, as well. Methods: A cross-sectional performed with 50 participants diagnosed xerostomia, randomly selected distributed in two groups: 25 hyposalivation without paired age sex. Unstimulated Salivary...