Abstract Background Inflammation is known to involve in many pathological processes of different diseases, but the current therapy causes adverse effects. Thus, there a great interest for discovery flavonoids as valuable alternative classical analgesic and anti-inflammatory agent with dual-inhibitory action, especially on both COX-2 5-LOX which can minimize or overcome this problem. Results In ...

BACKGROUND The US Food and Drug Administration has issued warnings about a potential link between leukotriene receptor-modifying agents (LTMA) and suicide. These warnings are based on case reports and there is controversy about the association. While spontaneous reporting of suicide-related events attributed to LTMA has risen dramatically, these data may be biased by the warnings. The objective...