Hydroxyurea was administered in a clinical trial to fourteen patients with documented disseminated malignant melanoma. The drug was not found to be useful as the sole agent in this neoplastic disorder in the dosage regimen outlined. The response of three patients receiving radiotherapy to metastatic brain lesions in combination with hydroxyurea was encouraging enough to warrant a further evalua...

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Peroxisome proliferator-activated receptor (PPAR) alpha ligands (Wy-14,643, and fenofibrate) and PPARgamma ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zi...