Epstein-Barr virus (EBV) immediate-early protein Zta is a member of the basic-leucine zipper (B-ZIP) family of DNA binding proteins that has an unusual capacity to recognize multiple DNA recognition sites, including AP-1 and C/EBP binding sites. To better understand the structure and function of Zta, we have mutagenized cysteine residues within or adjacent to the B-ZIP domain. We found that ser...

BACKGROUND Increasing attention is being paid to the marked disparities in diabetes prevalence and health outcomes in the United States. There is a need to identify the small-area geographic variation in diabetes risk and related outcomes, a task that current health surveillance methods, which often rely on a self-reported diagnosis of diabetes, are not detailed enough to achieve. Broad adoptio...

To the Editor: A recent perspective in this journal (1) pointed out problems with the present, county-referenced system for reporting spatial epidemiologic data. Problems identi-fi ed included coarse spatial resolution of county-referenced data and differences across the United States in size of counties, making data for the western part of the country coarser in resolution than data for the ea...

PRIMARY LUNG DISEASE, the associated inflammatory response, and treatment with supplemental oxygen all result in the generation of increased amounts of reactive oxygen species (ROS), which can cause significant damage to the lung. The susceptibility of the lung to oxidative injury depends largely on the ability to upregulate protective ROS scavenging systems. Unfortunately, both intracellular a...