Results Examples will be given in a number of diseases but focusing on breast cancer and the results from the AZURE trial on the use of zoledronic acid, as well as from CALGBB trial 9741 which evaluated a dose-dense treatment strategy, as proposed by Norton and Simon. Results will be presented, including quantification of the cellkilling effect of zoledronic acid from the AZURE trial, which dem...

Background : Menopause is the period during which systemic oestrogen level is reduced. During postmenopausal period, bone remodelling cycle is distorted and is occasionally associated with low bone mass which is the major determinant of bone strength. Zoledronic acid, a third generation bisphosphonates available as an alternative formulation approved for the treatment of postmenopausal women. A...

Zoledronic acid (ZA) is a bisphosphonate given intravenously, most commonly for the treatment of postmenopausal osteoporosis. Increase in usage of ZA because it was FDA-approved has resulted in increasing reports of side effects. For the most part, these are systemic. Cutaneous side effects associated with ZA are infrequent and limited to 2 reports of dermatomyositis to date. In both, patients ...

BACKGROUND The aim of the study was evaluation of zoledronic acid with regard to safety, effect on analgesic consumption and impact on occurrence of skeletal related events in patients with bone lesions from solid tumors and multiple myeloma. METHODS We conducted an observational, 12-month, phase IV and multi-center study. One hundred and twenty-five symptomatic (pain) bone-metastatic patient...

These highlights do not include all the information needed to use ZOMETA safely and effectively. See full prescribing information for ZOMETA. ZOMETA (zoledronic acid) Injection Ready-to-Use Solution for Intravenous Infusion (For Single Use) Concentrate for Intravenous Infusion Initial U.S. Approval: 2001 ----------------------------RECENT MAJOR CHANGES-------------------------Warnings and Preca...

BACKGROUND In the absence of head-to-head trials, indirect comparisons of randomized placebo-controlled trials may provide a viable option to assess relative efficacy. The purpose was to estimate the relative efficacy of reduction of fractures in post-menopausal women, and to assess robustness of the results. METHODS A systematic literature review of multiple databases identified randomized p...