Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-γ (IFN-γ) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-γ response by using a Quantiferon-Leishmania assay against three Leishmania peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to w...

In Morocco, as in most countries around the Mediterranean, leishmaniasis is an important public health problem. The situation has become worrying since the 1970’s and continues to be more complicated. The objective of this work was to realize a historical overview of the classification, evolution, and dispersion of Leishmania parasites and Sandflies in Morocco. The status of the different leish...

Following an epidemiological survey of zoonotic cutaneous leishmaniasis (ZCL) in several villages of Badrood, a rural district north of the city of Natanz, central Iran, Phlebotomus (Phlebotomus) papatasi Scopoli were found to be naturally infected with Leishmania (Leishmania) major zymodeme MON-26. Sand flies were collected and dissected biweekly from rodent burrows from May to October 2001. L...

Shifts in surface climate may have changed the dynamic of zoonotic cutaneous leishmaniasis (ZCL) in the pre-Saharan zones of North Africa. Caused by Leishmania major, this form multiplies in the body of rodents serving as reservoirs of the disease. The parasite is then transmitted to human hosts by the bite of a Phlebotomine sand fly (Diptera: Psychodidae) that was previously fed by biting an i...

background : zoonotic cutaneous leishmaniasis (zcl), an important public health problem in iran, is sensitive to climate conditions. this study aimed to examine dynamic relations between the climate factors and incidence of zcl in golestan province, northern iran during 2010–2012. methods : data of monthly climatic factors, including temperature variables, relative humidity variables, evaporati...

introduction cutaneous leishmaniasis (cl) is one of the most important zoonotic diseases in iran. according to the reports of the center for disease management and control, among the 20,000 cases infected with various types of leishmaniasis annually, 80% are zoonotic cutaneous leishmaniasis (zcl). this descriptive and retrospective study was performed to determine the most recent status of zcl ...

Cutaneous leishmaniasis ranks among the tropical diseases least known and most neglected in Libya. World Health Organization reports recognized associations of Phlebotomus papatasi, Psammomys obesus, and Meriones spp., with transmission of zoonotic cutaneous leishmaniasis (ZCL; caused by Leishmania major) across Libya. Here, we map risk of ZCL infection based on occurrence records of L. major, ...

To the Editor: Recent reports from Afghanistan have focused on the current status of war-and refugee-related anthroponotic cutaneous leishmaniasis (ACL), caused by Leishmania tropica, in Kabul City, refugee camps, and Fayzabad City (Badakhshan Province) (1–4). In central Asia, ACL is transmitted mainly by the sandfly Phlebotomus sergenti in urban or peri-urban environments (5). Zoonotic cutaneo...

Both cutaneous and visceral forms of leishmaniasis are prevalent in some parts of the Islamic Republic of Iran [1,2]. The Mediterranean type of visceral leishmaniasis (VL) is also reported sporadically throughout the country [3] with canines being the main animal reservoir hosts [4]. The cutaneous form of leishmaniasis is seen in 2 forms: anthroponotic and zoonotic. Anthroponotic cutaneous leis...

Meriones shawi (M.shawi) is the main reservoir host for zoonotic cutaneous leishmaniasis (ZCL) in Central Tunisia. The incorporation of environmental and climatic effects on spread ZCL M. remains difficult. This study presents an agent-based model (ABM) to overcome these difficulties examine impact environment (i.e. vegetation cover) climate temperature) movement prevalence. simulation consider...