Enantiopure N(Boc)-β(3)-amino nitriles, valuable synthetic intermediates in the multistep homologation of α-amino acids, were alkylated using n-BuLi as base. Alkylations afforded easily separable, almost equimolecular mixtures of diastereomeric N(Boc)-protected syn and anti β(2,3)-amino nitriles. Suitable manipulations of both cyano and amino groups eventually led to enantiopure N- and/or C-pro...

Chiral pool α-amino acids have been used as powerful tools for the total synthesis of structurally diverse natural products. Some common naturally occurring α-amino acids are readily available in both enantiomerically pure forms. The applications of the chiral pool in asymmetric synthesis can be categorized prudently as chiral sources, devices, and inducers. This review specifically examines re...

Correction for ‘Stereo-selective synthesis of non-canonical γ-hydroxy-α-amino acids by enzymatic carbon–carbon bond formation’ Rui Zhang et al. , Catal. Sci. Technol. 2021, 11 7380–7385, https://doi.org/10.1039/D1CY00955A.

In our previous study, we compared the two α-amylase enzymes from Bacillus sp.KR8104, BKA∆(N44) and BKA∆(N44C193) which is the secreted form of it. The results indicated that the presence of 193 amino acids propeptide in the C-terminal of BKA∆(N44) changed its enzymatic parameters like an uncompetitive inhibitor in comparison to BKA∆(N44C193). In the present study, we cloned the DNA sequence of...

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of α-amino acids, which function primarily as hair- and skin-conditioning agents in cosmetic products. The safety of α-amino acids as direct food additives has been well established based on extensive research through acute and chronic dietary exposures. The Panel focused its review on dermal irritation and sensitization da...

Fluorescence spectroscopy has become a powerful technique for probing a range of complex biological processes including enzyme mechanisms and protein-protein interactions. While the application of this technique uses a number of strategies, many of these rely on the use of fluorescent α-amino acids. This review highlights the recent synthetic methods developed for the incorporation of highly co...

The origin of amino acids in meteorites is not yet well understood, in spite of extensive molecular, isotopic, and chiral analyses of the last thirty years that have elucidated many of these compounds' features and distribution. The present general view of meteoritic amino acid formation is that of an interstellar/planetary sequence of Strecker-like reactions between aldehydes/ketones, HCN, wat...

The rapid recovery of the Winchcombe meteorite offers a valuable opportunity to study soluble organic matter (SOM) profile in pristine carbonaceous astromaterials. Our interests biologically relevant molecules, amino acids—monomers protein, and most prevalent meteoritic organics—polycyclic aromatic hydrocarbons (PAHs) are addressed by analyzing solvent extracts stone using gas chromatography ma...

amino acids (aa) are important in poultry nutrition not only for protein deposition, but also for other metabolic functions; such as improving immune and gut functions. although, some table values are available on amino acids requirement, aa requirements may vary due to changes in dietary composition and breeding selection. thus amino acids requirements have remained an ongoing research topic. ...