the purpose of this investigation was to determine the antioxidant potentials and anti-glucosidase activities of six tropical medicinal plants. the levels of phenolic constituents in these medicinal plants were also quantified and compared. antioxidation potentials were determined colorimetrically for scavenging activities against dpph and no radicals. metal chelating assay was based on the mea...

Fruits of the plant Ficus Lacor Buch. Ham. were used traditionally for treatment diabetes mellitus. The present study was undertaken to evaluate antidiabetic potential using in vitro approach. Effect evaluated α/β -glucosidase, α-amylase and lipase enzyme inhibition assay methods. glucose absorption intestine everted rat jejunum while uptake isolated hemidiaphragm. Fruit cork ethanolic extract ...

This study was designed to investigate whether Sargassum ringgoldianum extract may inhibit α-glucosidase and α-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. The IC50 values of Sargassum ringgoldianum extract against α-glucosidase and α-amylase were 0.12 mg/mL and 0.18 mg/mL, respectively, which evidenced higher activities than those of aca...

This study evaluated the in vitro antioxidative activity of Khaya senegalensis extracts and inhibitory effects of some solvent fractions on α-glucosidase and α-amylase activities. The stem bark, root and leaf samples of the plant were sequentially extracted with ethyl acetate, ethanol and water and then tested for antioxidative activity. Our findings revealed that the ethanolic extract of the r...

BACKGROUND In the present study, we tested a 50% ethanolic extract of Orthosiphon stamineus plants and its isolated bioactive compound with respect to their α-glucosidase and α-amylase inhibitory activities. METHODS Bioactive flavonoid sinensetin was isolated from 50% ethanolic extract of Orthosiphon stamineus. The structure of this pure compound was determined on the NMR data and the α-gluco...

BACKGROUND Some Ficus species have been used in traditional African medicine in the treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo but the mechanism of activity remains uncertain. The aim of this study was to determine the activity and to investigate the mechanism of antidiabetic activity of ten selected Ficus species through inhibition of α-amyl...

OBJECTIVE To evaluate the anti-hyperglycemic potential of sinigrin using in vitro, in silico and in vivo streptozotocin (STZ) induced hyperglycemic zebrafish model. METHODS The in vitro enzyme inhibition assay was carried out to determine the IC50 value against α-glucosidase and α-amylase, in silico molecular docking was performed against both enzymes with PyRx tool and simulations were perfo...

Objective: The present study was planned to explore phytoconstituents and hypoglycemic potential of the leaf extracts of Acanthus ilicifolius and Evolvulus emerginatus by invitro method. Methods: The aqueous, ethanol and methanol leaf extracts were prepared by soxhlation method. Qualitative phytochemical screening was done by using Horborne method. Methanol leaf extracts and standard drug acarb...

There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study was to provide in vitro evidence for potential inhibition of α-glucosidase and α-amylase enzymes, followed by a confirmatory in vivo study on rats to generate a strong...