The contents of total phenol and flavonoid 27 edible plants as well their antioxidative digestive enzymes inhibitory activities were evaluated. content the ranged from 1.28-46.80 mg gallic acid equivalent/g. DPPH, ABTS reducing power assay explored that Rubus idaeus Linn, Hibiscus sabdariffa Linn. Crataegus pinnatifida Bge. exhibited stronger antioxidant capacity among plants. 4 showed percenta...

The objective of the present study was to evaluate the inhibitory properties of various extracts of propolis on alpha-glucosidase from baker's yeast and mammalian intestine. Inhibitory activities of aqueous ethanol extracts of propolis were determined by using 4-nitrophenyl-D-glucopyranoside, sucrose and maltose as substrates, and acarbose as a positive reference. All extracts were significantl...

Cladonia foliacea (CF) is a type of lichen belonging to the Cladoniaceae family, used as traditional medicine for various diseases. It known that CF has strong antioxidant and antidiabetic effects originating from secondary components. However, bioactivity significantly affected by extraction conditions such temperature, liquid/solid ratio, solvent type/concentration. Herein, parameters (temper...

BACKGROUND α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that catalyzes hypoxanthine and xanthine to uric acid which at high levels can lead to hyperuricemia which is an important cause of gout. Pancreatic lipase (PL) secreted into the duodenum ...

Diabetes is considered one of the biggest health crises in 21st century. Controlling carbohydrate digestibility by inhibiting starch digestive enzyme (α-amylase and α-glucosidase) activities an efficient strategy to control postprandial hyperglycemia. Over last decade, synthetic inhibitors are most effective pharmaceutical approach for management type 2 diabetes mellitus (T2DM). With increasing...

Phytochemical investigation on the stems of C. tabularis (Meliaceae) led to the isolation of two new phragmalin-type limonoids, named tabularisins S and T (1-2), along with five known ones (3-7). The structures of the new limonoids were established by spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. All the compounds were evaluated for α-glucosidase inhibitory activity in vit...

An epimer of the known glycosidase inhibitor noeurostegine, galacto-noeurostegine, was synthesised in 21 steps from levoglucosan and found to be a potent, competitive and highly selective galactosidase inhibitor of Aspergillus oryzae β-galactosidase. Galacto-noeurostegine was not found to be an inhibitor of green coffee bean α-galactosidase, yeast α-glucosidase and E. coli β-galactosidase, wher...

Gymnema sylvestre (GS) is a powerful antidiabetic plant that has been utilized in ayurvedic, folk and homeopathic medicine for centuries. In this research, we evaluated the potential of methanolic leaf extract sylvestre. Fractionation was carried out using column chromatography total twenty-eight (28) sub-fractions were obtained which further screened pooled into three (3) fractions (A, B C) by...

Background This study compared the contents of extracts Chenopodium formosanum (Djulis) originating from 2 aboriginal areas (Kaohsiung and Taitung, Taiwan) evaluated their efficacy in ameliorating insulin resistance vitro. Methods First, we analyzed anti-oxidant compositions activity, α-glucosidase, α-amylase inhibitory effects Djulis extracts, then ability to ameliorate HepG2 cell. To do this,...

Background. This study sought to investigate the antioxidant and antihyperglycemic properties of Musa sapientum (Latundan banana) (MSL), Musa acuminata (Cavendish banana) (MAC), and Musa acuminate (Red Dacca) (MAR). Materials and Methods. The sugar, starch, amylose, and amylopectin contents and glycemic index (GI) of the three banana cultivars were determined. Furthermore, total phenol and vita...